Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Department of Radiology, School of Medicine, International University of Health and Welfare, Chiba, Japan.
Thorac Cancer. 2024 Jan;15(2):201-205. doi: 10.1111/1759-7714.15158. Epub 2023 Nov 20.
Adenoid cystic carcinoma (ACC) of the trachea is a rare disease that is slow growing and has a risk of distant metastasis. The standard treatment for ACC of the trachea is surgery, but this tumor is often unresectable. In definitive radiotherapy using photons for unresectable ACC of the trachea, it is sometimes difficult to deliver a sufficient dose to the target without exceeding the tolerable dose to the surrounding normal tissues. Here, we report two cases of ACC of the trachea that received a high dose (74 Gy [relative biological effectiveness]) of proton beam therapy and achieved long-term survival.
气管腺样囊性癌（ACC）是一种罕见的疾病，生长缓慢，有远处转移的风险。气管 ACC 的标准治疗方法是手术，但这种肿瘤往往无法切除。在使用光子进行无法切除的气管 ACC 的确定性放疗中，有时很难在不超过周围正常组织可耐受剂量的情况下将足够的剂量递送到靶区。在这里，我们报告了两例接受高剂量（74Gy[相对生物效应]）质子束治疗的气管 ACC 病例，均实现了长期生存。
