Schumacher Benjamin T, Rosano Caterina, Qiao Yujia Susanna, Rosso Andrea L, Cawthon Peggy M, Moored Kyle D, Cummings Steven R, Kritchevsky Stephen B, Glynn Nancy W
medRxiv. 2023 Nov 7:2023.11.06.23298173. doi: 10.1101/2023.11.06.23298173.
Emerging evidence shows that perceived fatigability-the quantification of vulnerability to fatigue in relation to specific intensity and duration of activities-may be associated with cognitive function. We sought to quantify associations with multiple domains of cognitive function and the role of physical activity (PA).
SOMMA participants completed the Pittsburgh Fatigability Scale (PFS) Physical and Mental subscales (each range 0-50; higher scores=greater fatigability) and three cognitive function assessments [Digit Symbol Substitution Test (DSST), executive function; Montreal Cognitive Assessment (MoCA), general function; and California Verbal Learning Test (CVLT), memory]. Linear regression quantified associations cross-sectionally between each PFS subscale and cognitive assessment scores adjusting for covariates. Effect modification by volume and intensity of accelerometer-measured PA was assessed.
In 873 participants (59.2% women; age 76.3±5.0; 85% White), mean PFS Physical, Mental, and DSST scores were 15.8±8.7, 7.7±7.8, and 55.4±13.7. After adjustments, for each 4-point higher PFS Physical and 3-point higher PFS Mental, participants had nearly one fewer correct DSST items [β coefficient and 95% confidence interval for PFS Physical: -0.69 (-1.09, - 0.29); PFS Mental: -0.64 (-0.97, -0.30)]. Volume and intensity of PA modified the association of PFS Mental and DSST ( <0.01). All associations were strongest in those with the lowest volume and intensity of PA. PFS was not associated with MoCA or CVLT.
Greater perceived fatigability may be associated with poorer executive function, but not memory. Individuals with greater perceived fatigability, particularly those less active, might benefit from interventions that reduce fatigability and may beneficially influence cognitive function.
新出现的证据表明，可感知疲劳性——与特定活动强度和持续时间相关的疲劳易感性量化指标——可能与认知功能有关。我们试图量化与认知功能多个领域的关联以及身体活动（PA）的作用。
SOMMA研究参与者完成了匹兹堡疲劳量表（PFS）的身体和精神分量表（每个分量表范围为0 - 50；分数越高 = 疲劳感越强）以及三项认知功能评估[数字符号替换测验（DSST），执行功能；蒙特利尔认知评估量表（MoCA），一般功能；加利福尼亚言语学习测验（CVLT），记忆]。线性回归用于横断面量化每个PFS分量表与认知评估分数之间的关联，并对协变量进行调整。评估了通过加速度计测量的PA的量和强度的效应修正。
在873名参与者中（59.2%为女性；年龄76.3±5.0；85%为白人），PFS身体、精神和DSST的平均得分分别为15.8±8.7、7.7±7.8和55.4±13.7。调整后，PFS身体得分每高4分以及PFS精神得分每高3分，参与者的DSST正确项目数就会减少近1个[PFS身体的β系数和95%置信区间：-0.69（-1.09，-0.29）；PFS精神：-0.64（-0.97，-0.30）]。PA的量和强度修正了PFS精神与DSST之间的关联（P<0.01）。所有关联在PA量和强度最低的人群中最强。PFS与MoCA或CVLT无关。
更高的可感知疲劳性可能与较差的执行功能有关，但与记忆无关。可感知疲劳性较高的个体，尤其是那些活动较少的个体，可能会从减少疲劳的干预措施中受益，并且可能对认知功能产生有益影响。
