Dongjiu Campus, Jiangnan University Yixing Graduate School, China.
Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
J Mater Chem B. 2023 Nov 29;11(46):11094-11102. doi: 10.1039/d3tb02017g.
Covalent organic frameworks (COFs) have promising applications in enhanced phototherapy. However, COFs that can sustainably play a role in phototherapy without continuous irradiation are extremely scarce. Herein, we report the fabrication of porphyrin-anthracene multifunctional COFs (Por-DPA) for sustainable photosterilization and bacterial-infected wound healing. A porphyrin photosensitizer, as one of the monomers, was used to provide photothermal and photodynamic activities under irradiation. An anthracene derivative, a good chemical source of singlet oxygen (O), was selected as another monomer to capture O and release it continuously cycloreversion in the dark. The prepared Por-DPA COF prevents the self-aggregation quenching of the photosensitizer and thermal damage caused by continuous exposure to external light sources. Besides, Por-DPA exhibits good photothermal conversion performance and efficient O production capacity through dual pathways of photosensitization and cycloreversion. The developed sustainable photosterilization platform not only has good bactericidal effects on and , but also promotes wound healing without obvious side effects, and is expected to be a novel efficient bactericide.
共价有机骨架（COFs）在增强光疗中有很有前途的应用。然而，能够在没有连续照射的情况下持续发挥光疗作用的 COFs 极为稀缺。在此，我们报告了卟啉-蒽多功能 COFs（Por-DPA）的制备，用于可持续的光杀菌和细菌感染伤口愈合。卟啉类光敏剂被用作单体之一，在辐照下提供光热和光动力活性。选择蒽衍生物作为另一种单体，以在黑暗中通过环化回返连续捕获 O 并释放它。所制备的 Por-DPA COF 防止了光敏剂的自聚集猝灭和由连续暴露于外部光源引起的热损伤。此外，Por-DPA 通过光致化和环化回返的双重途径表现出良好的光热转换性能和高效的 O 生成能力。所开发的可持续光杀菌平台不仅对 和 具有良好的杀菌效果，而且没有明显的副作用促进伤口愈合，有望成为一种新型的高效杀菌剂。
