High Frequency and Quantum Electronics, University of Siegen, 57076, Siegen, Germany.
Biochemistry and Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
Sci Rep. 2023 Nov 24;13(1):20708. doi: 10.1038/s41598-023-46876-5.
In this work, we present a promising diagnostic tool for melanoma diagnosis. With the proposed terahertz biosensor, it was possible to selectively and sensitively detect the early growth response protein 2, a transcription factor with an increased activity in melanoma cells, from a complex sample of cellular proteins. Fundamentally, the sensor belongs to the frequency selective surface type metamaterials and consists of a two-dimensional array of asymmetrically, doubly split ring resonator unit cells. The single elements are slits in a metallic layer and are complemented by an undercut etch. This allows a selective functionalization of the active area of the sensor and increases the sensitivity towards the target analyte. Hereby, specific detection of a defined transcription factor is feasible.
在这项工作中，我们提出了一种有前途的用于黑色素瘤诊断的诊断工具。通过所提出的太赫兹生物传感器，我们能够从细胞蛋白质的复杂样品中选择性和灵敏地检测早期生长反应蛋白 2，这是一种在黑色素瘤细胞中活性增加的转录因子。从根本上说，传感器属于频率选择表面类型超材料，由不对称、双分裂环谐振器单元的二维阵列组成。单个元件是金属层中的狭缝，并辅以刻蚀。这允许对传感器的有源区进行选择性功能化，并提高对目标分析物的灵敏度。通过这种方式，可以实现对特定转录因子的特异性检测。
