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退行性小脑共济失调患者的前庭康复疗效:一项回顾性队列研究

Effectiveness of Vestibular Rehabilitation for Patients with Degenerative Cerebellar Ataxia: A Retrospective Cohort Study.

作者信息

Heusel-Gillig Lisa L, Hall Courtney D

机构信息

Emory Dizziness and Balance Center, Emory University, Atlanta GA 30329, USA.

James H. Quillen Veterans Affairs Medical Center, Mountain Home, TN 37684, USA.

出版信息

Brain Sci. 2023 Oct 28;13(11):1520. doi: 10.3390/brainsci13111520.

Abstract

Many patients with cerebellar ataxia have dizziness caused by oculomotor or peripheral vestibular deficits; however, there is little evidence supporting the use of vestibular rehabilitation for this population. The purpose of this study was to determine whether patients with degenerative cerebellar diseases improve following rehabilitation including vestibular exercises. A secondary aim was to identify variables associated with the outcomes. A retrospective chart review identified 42 ambulatory patients (23 men and 19 women; mean age = 54.5 ± 14.4 years) with cerebellar degeneration. Fourteen patients had ataxia only, twenty had ataxia and oculomotor abnormalities, and eight had ataxia with oculomotor and peripheral vestibular deficits. Patients received customized physical therapy including balance and gait training, as well as gaze stabilization and habituation exercises for vestibular hypofunction and motion-provoked dizziness. Primary outcome measures (Activities-specific Balance Confidence Scale, Tinetti Performance Oriented Mobility Assessment, Dynamic Gait index, and Sensory Organization Test) were evaluated at baseline and discharge. Patients improved ( < 0.05) on all outcome measures. Patients with vestibular deficits were seen for more visits compared to those with gait ataxia only (7.1 vs. 4.8 visits). This study provides evidence that patients with degenerative cerebellar disease improve in balance confidence, fall risk and sensory integration with therapy that includes vestibular rehabilitation.

摘要

许多小脑性共济失调患者存在由眼球运动或外周前庭功能障碍引起的头晕;然而,几乎没有证据支持对该人群使用前庭康复治疗。本研究的目的是确定患有退行性小脑疾病的患者在包括前庭锻炼的康复治疗后是否有所改善。次要目的是确定与治疗结果相关的变量。一项回顾性病历审查确定了42例患有小脑变性的门诊患者(23名男性和19名女性;平均年龄 = 54.5 ± 14.4岁)。14例患者仅有共济失调,20例患者有共济失调和眼球运动异常,8例患者有共济失调伴眼球运动和外周前庭功能障碍。患者接受了定制的物理治疗,包括平衡和步态训练,以及针对前庭功能减退和运动诱发头晕的注视稳定和习服训练。在基线和出院时评估主要结局指标(特定活动平衡信心量表、Tinetti定向运动功能评估、动态步态指数和感觉统合测试)。所有结局指标均有改善(< 0.05)。与仅患有步态共济失调的患者相比,有前庭功能障碍的患者就诊次数更多(7.1次对4.8次)。本研究提供了证据表明,患有退行性小脑疾病的患者在接受包括前庭康复的治疗后,平衡信心、跌倒风险和感觉统合能力得到改善。

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