Preusser P, Wilke H, Achterrath W, Neuhaus B, Balleisen L, Meyer J, Van de Loo J
Anticancer Res. 1986 Sep-Oct;6(5):1195-6.
In a pilot study 16 patients with advanced inoperable stomach cancer were treated with Etoposide, Adriamycin, Cisplatin. The recommended dose for phase II studies was established and first therapy results are presented. Two of 16 patients responded with complete remissions and 8 with partial remissions. The recommended dose schedule for phase II studies is: Adriamycin 20 mg/m2 i.v. day 1 + 7; Cisplatin 40 mg/m2 i.v. day 2 + 8; Etoposide 120 mg/m2 i.v. day 4, 5, 6, every four weeks.
在一项初步研究中，16例晚期无法手术的胃癌患者接受了依托泊苷、阿霉素和顺铂治疗。确定了II期研究的推荐剂量，并给出了首次治疗结果。16例患者中有2例完全缓解，8例部分缓解。II期研究的推荐剂量方案为：阿霉素20mg/m²静脉注射，第1天和第7天；顺铂40mg/m²静脉注射，第2天和第8天；依托泊苷120mg/m²静脉注射，第4、5、6天，每四周一次。
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