Casteleiro Bárbara, Rocha Mariana, Sousa Ana R, Pereira André M, Martinho José M G, Pereira Clara, Farinha José P S
Centro de Química Estrutural, Institute of Molecular Sciences (IMS) and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.
REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.
Polymers (Basel). 2023 Nov 13;15(22):4392. doi: 10.3390/polym15224392.
Gold nanoclusters (AuNCs) with fluorescence in the Near Infrared (NIR) by both one- and two-photon electronic excitation were incorporated in mesoporous silica nanoparticles (MSNs) using a novel one-pot synthesis procedure where the condensation polymerization of alkoxysilane monomers in the presence of the AuNCs and a surfactant produced hybrid MSNs of 49 nm diameter. This method was further developed to prepare 30 nm diameter nanocomposite particles with simultaneous NIR fluorescence and superparamagnetic properties, with a core composed of superparamagnetic manganese (II) ferrite nanoparticles (MnFeO) coated with a thin silica layer, and a shell of mesoporous silica decorated with AuNCs. The nanocomposite particles feature NIR-photoluminescence with 0.6% quantum yield and large Stokes shift (290 nm), and superparamagnetic response at 300 K, with a saturation magnetization of 13.4 emu g. The conjugation of NIR photoluminescence and superparamagnetic properties in the biocompatible nanocomposite has high potential for application in multimodal bioimaging.
通过单光子和双光子电子激发在近红外（NIR）区域具有荧光的金纳米团簇（AuNCs），采用一种新颖的一锅合成法被掺入介孔二氧化硅纳米颗粒（MSNs）中。在该方法中，烷氧基硅烷单体在AuNCs和一种表面活性剂存在的情况下发生缩聚反应，生成了直径为49纳米的混合MSNs。该方法进一步发展用于制备直径为30纳米的具有同时近红外荧光和超顺磁性的纳米复合颗粒，其核心由包覆有薄二氧化硅层的超顺磁性锰（II）铁氧体纳米颗粒（MnFeO）组成，外壳是装饰有AuNCs的介孔二氧化硅。这些纳米复合颗粒具有量子产率为0.6%和大斯托克斯位移（290纳米）的近红外光致发光特性，以及在300 K时的超顺磁响应，饱和磁化强度为13.4 emu g。生物相容性纳米复合物中近红外光致发光与超顺磁性的结合在多模态生物成像中具有很高的应用潜力。
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