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莫德·门滕:开拓性的儿科-围产病理学家、临床科学家,以及“世界上最棒的人”。

Maud Menten: Pioneering Pediatric-Perinatal Pathologist, Clinician-Scientist, and "the Most Wonderful Human Being in the World".

机构信息

Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, AB, Canada.

出版信息

Pediatr Dev Pathol. 2024 Mar-Apr;27(2):107-122. doi: 10.1177/10935266231202934. Epub 2023 Nov 25.

Abstract

Maud Menten was born and raised in remote regions of Canada. She obtained her MB/MD at the University of Toronto (1907/1911) and her PhD in biochemistry at the University of Chicago (1916). From 1907 to 1916, she trained at the Rockefeller Institute for Medical Research, the New York Infirmary for Women and Children, Western Reserve University in Cleveland, the Berlin Municipal Hospital in Germany, and the Barnard Free Skin and Cancer Hospital in St Louis. In 1916, she was appointed as pathologist at the Elizabeth Steel Magee Hospital, a charitable maternity hospital in Pittsburgh. She received a faculty appointment at the University of Pittsburgh (1918) and was appointed pathologist at Pittsburgh Children's Hospital (1926). In addition to being one of the first woman academic pathologists, she was likely the first perinatal, the second pediatric-perinatal, and the fourth pediatric pathologist to practice in North America. The importance of Menten's overall scientific contributions place her in the very upper echelon of 20th century pathologists. Her enzyme kinetic work resulted in the Michaelis-Menten equation, and her work in George Crile's laboratory in Cleveland provided a physiological basis for improved surgical outcomes. Her work in Pittsburgh was equally innovative, including initiating the field of enzyme histochemistry.

摘要

莫德·门滕(Maud Menten)在加拿大偏远地区出生和长大。她在多伦多大学获得医学学士/医学博士学位(1907/1911 年),并在芝加哥大学获得生物化学博士学位(1916 年)。1907 年至 1916 年期间,她在洛克菲勒医学研究所、纽约妇女儿童医院、克利夫兰的西储大学、德国柏林市立医院和圣路易斯的巴纳德免费皮肤和癌症医院接受培训。1916 年,她被任命为匹兹堡伊丽莎白·斯蒂尔·马吉医院(Elizabeth Steel Magee Hospital)的病理学家,该医院是匹兹堡的一家慈善妇产医院。她于 1918 年在匹兹堡大学获得教职,并于 1926 年被任命为匹兹堡儿童医院的病理学家。作为首批女学术病理学家之一,她可能是北美第一位围产病理学家、第二位儿科-围产病理学家和第四位儿科病理学家。门滕整体科学贡献的重要性使她跻身 20 世纪病理学家的最高层之列。她的酶动力学工作导致了米氏方程的产生,而她在克利夫兰的乔治·克里尔(George Crile)实验室的工作为改善手术结果提供了生理学基础。她在匹兹堡的工作同样具有创新性,包括开创了酶组织化学领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e071/11015720/256b0e9e1271/10.1177_10935266231202934-fig1.jpg

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