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一例舌下腺黏膜相关淋巴组织淋巴瘤。

One case of sublingual gland mucosa-associated lymphoid tissue lymphoma.

机构信息

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430079 Wuhan, China; Dongfeng Stomatological Hospital, Hubei University of Medicine, 442000 Shiyan, China.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430079 Wuhan, China; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 430079 Wuhan, China.

出版信息

Oral Oncol. 2024 Jan;148:106648. doi: 10.1016/j.oraloncology.2023.106648. Epub 2023 Nov 25.

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of marginal zone B-cell lymphoma that occurs outside the lymph nodes in mucosal tissue. It accounts for 6-8 % of non-Hodgkin's lymphomas. MALT lymphoma of the salivary gland is a rare disease, with primary tumors in the salivary gland accounting for 2-5 % of salivary gland tumors. The most common site is the parotid gland (80 %), followed by the submandibular gland (14 %), minor salivary glands, and sublingual gland (5 %). Patients with salivary gland MALT lymphoma often have autoimmune diseases such as Sjogren's syndrome and rheumatoid arthritis. Primary malignant tumors of the sublingual gland account for less than 1 % of cases, and preoperative diagnosis is difficult, often requiring biopsy for confirmation. To our knowledge, there are no reports of MALT lymphoma arising from the sublingual gland. We report a case of MALT lymphoma originating from the sublingual gland in a patient with a history of hypertension, diabetes, cerebral infarction, and non-traumatic numbness of the right lower limb.

摘要

黏膜相关淋巴组织(MALT)淋巴瘤是一种发生在黏膜组织内淋巴结外的边缘区 B 细胞淋巴瘤,约占非霍奇金淋巴瘤的 6-8%。涎腺 MALT 淋巴瘤是一种罕见疾病,原发于涎腺的肿瘤占涎腺肿瘤的 2-5%。最常见的部位是腮腺(80%),其次是颌下腺(14%)、小唾液腺和舌下腺(5%)。涎腺 MALT 淋巴瘤患者常伴有自身免疫性疾病,如干燥综合征和类风湿关节炎。舌下腺原发性恶性肿瘤不到 1%,术前诊断困难,常需活检证实。据我们所知,尚无舌下腺 MALT 淋巴瘤的报道。我们报告了 1 例起源于舌下腺的 MALT 淋巴瘤病例,患者有高血压、糖尿病、脑梗死和右侧下肢非外伤性麻木病史。

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