Bamburowicz-Klimkowska Magdalena, Bystrzejewski Michal, Kasprzak Artur, Cieszanowski Andrzej, Grudzinski Ireneusz P
Department of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Department of Physical Chemistry, Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland.
Nanomedicine. 2024 Jan;55:102721. doi: 10.1016/j.nano.2023.102721. Epub 2023 Nov 24.
Integrin beta-3 is a cell adhesion molecule that mediate cell-to-cell and cell-to-extracellular matrix communication. The major goal of this study was to explore melanoma cells (B16F10) based upon specific direct targeting of the β3 subunit (CD61) in the integrin αvβ3 receptor using carbon-encapsulated iron nanoparticles decorated with monoclonal antibodies (Fe@C-CONH-anti-CD61 and Fe@C-(CH)-CONH-anti-CD61). Both melanoma cells treated with nanoparticles as well as C57BL/6 mice bearing syngeneic B16-F10 tumors intravenously injected with nanoparticles were tested in preclinical MRI studies. The as-synthesized carbon-encapsulated iron nanoparticles functionalized with CD61 monoclonal antibodies have been successfully used as a novel targeted contrast agent for MRI-based tracking melanoma cells expressing the β3 subunit of the integrin αvβ3 receptor.
整合素β-3是一种细胞粘附分子，介导细胞间和细胞与细胞外基质的通讯。本研究的主要目的是基于用单克隆抗体修饰的碳包铁纳米颗粒（Fe@C-CONH-抗CD61和Fe@C-(CH)-CONH-抗CD61）对整合素αvβ3受体中的β3亚基（CD61）进行特异性直接靶向，来探索黑色素瘤细胞（B16F10）。在临床前MRI研究中，对用纳米颗粒处理的黑色素瘤细胞以及静脉注射纳米颗粒的携带同基因B16-F10肿瘤的C57BL/6小鼠进行了测试。用CD61单克隆抗体功能化的合成碳包铁纳米颗粒已成功用作一种新型靶向造影剂，用于基于MRI追踪表达整合素αvβ3受体β3亚基的黑色素瘤细胞。
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