生物学支柱：基因调控网络的布尔建模。

Pillars of biology: Boolean modeling of gene-regulatory networks.

机构信息

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, USA; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, USA.

出版信息

J Theor Biol. 2024 Feb 7;578:111682. doi: 10.1016/j.jtbi.2023.111682. Epub 2023 Nov 25.

DOI:10.1016/j.jtbi.2023.111682

PMID:38008156

Abstract

Boolean modeling is a mathematical modeling framework used for defining and studying gene-regulatory networks (GRNs). It serves as a means to develop mechanistic models, offering insights into the trajectories and dynamic properties of GRNs. In this review, I delve into seminal papers published in the Journal of Theoretical Biology that have spearheaded this field. Additionally, I explore the application of these modeling methods in the current era of data-intensive science.

摘要

布尔建模是一种用于定义和研究基因调控网络 (GRNs) 的数学建模框架。它是开发机制模型的一种手段，可以深入了解 GRNs 的轨迹和动态特性。在这篇综述中，我深入研究了在《理论生物学杂志》上发表的开创性论文，这些论文推动了这一领域的发展。此外，我还探讨了这些建模方法在当前数据密集型科学时代的应用。