在职和新入职消防员血清全氟和多氟烷基物质浓度比较及新入职消防员的纵向评估。
Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits.
机构信息
From the Environmental Health Sciences, Mel and Enid Zuckerman School of Public Health, The University of Arizona, Tucson, Arizona (A.J.N., M.A.F., P.I.B., S.C.B., S.R.L., J.L.B.); BIO5 Institute, Statistics Consulting Laboratory, The University of Arizona, Tucson, Arizona (J.M.F.); University of Michigan School of Public Health, Ann Arbor, Michigan (J.M.Go.); School of Public Health, Rutgers, The State University of New Jersey, Piscataway, New Jersey (J.M.Gr.); Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia (A.M.C.); Tucson Fire Department, Tucson, Arizona (J.J.G.); and Sarasota County Fire Department, Sarasota, Florida (D.D.W.).
出版信息
J Occup Environ Med. 2024 Mar 1;66(3):202-211. doi: 10.1097/JOM.0000000000003020. Epub 2023 Nov 3.
OBJECTIVE
Firefighters are occupationally exposed to per- and polyfluoroalkyl substances (PFAS). This study objective was to compare serum PFAS concentrations in incumbent and recruit firefighters and evaluate temporal trends among recruits.
METHODS
Serum PFAS concentrations were measured in 99 incumbent and 55 recruit firefighters at enrollment in 2015-2016, with follow-up 20 to 37 months later for recruits. Linear and logistic regression and linear mixed-effects models were used for analyses. Fireground exposure impact on PFAS concentrations was investigated using adjusted linear and logistic regression models.
RESULTS
Incumbents had lower n-PFOA and PFNA than recruits and most PFAS significantly decreased over time among male recruits. No significant links were found between cumulative fireground exposures and PFAS concentrations.
CONCLUSIONS
Serum PFAS concentrations were not increased in incumbent firefighters compared with recruits and were not associated with cumulative fireground exposures.
目的
消防员职业性接触全氟和多氟烷基物质（PFAS）。本研究的目的是比较在职和新入职消防员的血清 PFAS 浓度，并评估新入职消防员中的时间趋势。
方法
2015-2016 年，在入职时对 99 名在职和 55 名新入职消防员进行了血清 PFAS 浓度测量，随后对新入职消防员进行了 20 至 37 个月的随访。线性和逻辑回归以及线性混合效应模型用于分析。使用调整后的线性和逻辑回归模型调查了火灾现场暴露对 PFAS 浓度的影响。
结果
在职消防员的 n-PFOA 和 PFNA 浓度低于新入职消防员，且大多数 PFAS 浓度在男性新入职消防员中随时间显著下降。累计火灾现场暴露与 PFAS 浓度之间未发现显著关联。
结论
与新入职消防员相比，在职消防员的血清 PFAS 浓度并未升高，且与累计火灾现场暴露无关。
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