Department of Thoracic Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Int Wound J. 2024 Mar;21(3):e14525. doi: 10.1111/iwj.14525. Epub 2023 Nov 27.
Surgical site infections (SSIs) post-thoracoscopic radical resection in lung cancer patients pose significant clinical challenges. This study aims to comprehensively identify the independent risk factors that influence the occurrence of SSIs following thoracoscopic radical resection for lung cancer. The study employed a retrospective analysis of 130 patients who underwent thoracoscopic radical resection for lung cancer. Inclusion and exclusion criteria were clearly defined, and ethical approvals were obtained. Patients were monitored for SSIs via clinical and biochemical markers, with data comprehensively gathered from electronic health records. Statistical analysis was rigorously conducted using SPSS v27.0, with methodologies including t-tests, Chi-square tests and logistic regression. The study aimed to identify independent risk factors for SSIs and incorporated a multidimensional assessment approach to provide robust, clinically relevant findings. Univariate analysis revealed surgical duration ≥3 h, non-usage of antibiotics, presence of diabetes and elevated levels of C-reactive protein (CRP) and procalcitonin (PCT) as significant correlates for SSIs. Multivariate analysis substantiated these factors as independent risk variables: surgery duration (odds ratio [OR] = 9.698, p < 0.05), presence of diabetes (OR = 6.89, p < 0.05), elevated CRP (OR = 7.306, p < 0.05) and elevated PCT (OR = 6.838, p < 0.05). Conversely, antibiotic administration served as a protective factor (OR = 0.572, p < 0.05). Surgical duration of 3 h or more, diabetes and elevated levels of CRP and PCT significantly heighten the risk for SSIs after thoracoscopic radical resection in lung cancer patients. Perioperative antibiotic administration acts as a protective factor. Clinicians should implement tailored preventative strategies to mitigate these identified risks.
肺癌患者胸腔镜根治术后的手术部位感染（SSI）是一个重大的临床挑战。本研究旨在全面确定影响肺癌胸腔镜根治术后 SSI 发生的独立危险因素。该研究对 130 例行胸腔镜根治性肺癌切除术的患者进行回顾性分析。明确了纳入和排除标准，并获得了伦理批准。通过临床和生化标志物监测患者的 SSI，从电子健康记录中全面收集数据。使用 SPSS v27.0 进行严格的统计分析，方法包括 t 检验、卡方检验和逻辑回归。本研究旨在确定 SSI 的独立危险因素，并采用多维评估方法提供稳健、具有临床相关性的发现。单因素分析显示手术时间≥3 小时、未使用抗生素、合并糖尿病以及 C 反应蛋白（CRP）和降钙素原（PCT）水平升高与 SSI 显著相关。多因素分析证实这些因素为独立的风险变量：手术时间（优势比 [OR] = 9.698，p < 0.05）、合并糖尿病（OR = 6.89，p < 0.05）、CRP 升高（OR = 7.306，p < 0.05）和 PCT 升高（OR = 6.838，p < 0.05）。相反，抗生素的使用则是一个保护因素（OR = 0.572，p < 0.05）。手术时间≥3 小时、糖尿病以及 CRP 和 PCT 水平升高显著增加了肺癌患者胸腔镜根治术后 SSI 的风险。围手术期抗生素的使用是一个保护因素。临床医生应实施针对性的预防策略来降低这些已确定的风险。
