肿瘤芽生用于研究头颈癌的局部侵袭、转移及预后：一项系统评价
Tumor budding to investigate local invasion, metastasis, and prognosis of head and neck carcinoma: A systematic review.
作者信息
Zanoletti Elisabetta, Daloiso Antonio, Nicolè Lorenzo, Cazzador Diego, Mondello Tiziana, Franz Leonardo, Astolfi Laura, Marioni Gino
机构信息
Otolaryngology Section, Department of Neuroscience DNS, University of Padova, Padova, Italy.
Department of Medicine (DIMED), University of Padova, Padova, Italy.
出版信息
Head Neck. 2024 Mar;46(3):651-671. doi: 10.1002/hed.27583. Epub 2023 Nov 28.
The aim of this systematic review is to shed light on the role of tumor budding (TB) in the biology, behavior, and prognosis of head and neck squamous cell carcinoma (HNSCC). A search was run in PubMed, Scopus, and Embase databases following PRISMA guidelines. After full-text screening and application of inclusion/exclusion criteria, 36 articles were included. Several investigations support the prognostic role of TB, which might play a role in selecting rational treatment strategies. To achieve this goal, further research is needed for greater standardization in TB quantification. Although TB is not included as a negative prognostic factor in the current management guidelines, it might be reasonable to consider a closer follow-up for HNSCC cases with high histopathological evidence of TB.
本系统评价的目的是阐明肿瘤芽生（TB）在头颈部鳞状细胞癌（HNSCC）的生物学、行为和预后中的作用。按照PRISMA指南在PubMed、Scopus和Embase数据库中进行了检索。经过全文筛选并应用纳入/排除标准后，纳入了36篇文章。多项研究支持TB的预后作用，其可能在选择合理的治疗策略中发挥作用。为实现这一目标，需要进一步研究以实现TB定量的更大标准化。尽管TB在当前的管理指南中未被列为负面预后因素，但对于具有高度组织病理学证据显示TB的HNSCC病例，考虑进行更密切的随访可能是合理的。
Zotero 插件