[肝素在红细胞聚集中的作用]
[Role of heparin in erythrocyte aggregation].
作者信息
Bychkov S M, Kuz'mina S A
出版信息
Biull Eksp Biol Med. 1986 Dec;102(12):692-5.
The effect of two heparin fractions containing 3 (HP-3) and 4 (HP-4) residues of sulfuric acid per dimer of polymers on the capacity of hyaluronate potassium (HUP) and protein-chondroitin-keratan-sulfate potassium (PCHKSP) to aggregate rabbit erythrocytes suspended in 0.15 M NaCl was studied. HP-3 (0.3-5.0 mg X ml-1) and HP-4 (0.3-5.0 mg X ml-1) was inhibited the aggregating action on the erythrocytes of HUP. Fraction HP-3 (0.3-5.0 mg X ml-1) was activated the aggregating action on the erythrocytes of PCHKSP. Fraction HP-4 when the concentration of their biopolymer were 0.3 mg X ml-1 so activated the aggregating action of PCHKSP, but when the concentration HP-4 0.6-5.0 mg X ml-1 was inhibited the aggregating action PCHKSP. The mixture of HP-3 (1.2 mg X ml-1) and HP-4 (1.2 mg X ml-1) was not influenced on aggregating action of PCHKSP.
研究了聚合物每二聚体含3个（HP - 3）和4个（HP - 4）硫酸残基的两种肝素级分对透明质酸钾（HUP）和蛋白 - 硫酸软骨素 - 硫酸角质素钾（PCHKSP）聚集悬浮于0.15 M NaCl中的兔红细胞能力的影响。HP - 3（0.3 - 5.0 mg·ml⁻¹）和HP - 4（0.3 - 5.0 mg·ml⁻¹）抑制了HUP对红细胞的聚集作用。HP - 3级分（0.3 - 5.0 mg·ml⁻¹）激活了PCHKSP对红细胞的聚集作用。当HP - 4级分的生物聚合物浓度为0.3 mg·ml⁻¹时激活了PCHKSP的聚集作用，但当HP - 4浓度为0.6 - 5.0 mg·ml⁻¹时抑制了PCHKSP的聚集作用。HP - 3（1.2 mg·ml⁻¹）和HP - 4（1.2 mg·ml⁻¹）的混合物对PCHKSP的聚集作用没有影响。
Zotero 插件