Older People and Frailty, NIHR Policy Research Unit, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.
School of Nursing, Midwifery & Paramedic Practice, Robert Gordon University, Aberdeen, AB10 7QG, UK.
Arch Gerontol Geriatr. 2024 Mar;118:105282. doi: 10.1016/j.archger.2023.105282. Epub 2023 Nov 23.
With the increasing global burden of frailty on healthcare resources, it is important to understand the modifiable risk factors of frailty. This study examined perceived age discrimination as a potential risk factor for frailty progression and frailty development among older adults.
Prospective cohort study using data from Waves 5 to 9 of the English Longitudinal Study of Ageing (ELSA). Data on perceived age discrimination was collected only in Wave 5 of ELSA and analysed as baseline data in this study. Frailty was defined using the Frailty Index (FI) scores (0 to 1), calculated using the multidimensional deficits (scores ≥ 0.25 were considered frail). Binomial generalised estimating equation models (GEE) were fitted in R studio using perceived age discrimination as the main predictor with age, gender, long-standing illness, cognition, subjective social status status (SSS) and psychological wellbeing as covariates. Odd ratios were reported with 95 % confidence intervals (CI).
A total sample of 2,385 ELSA participants were included in the analysis. 55.8 % (n = 1312) were female, mean age 71.9 (SD ± 5.27) years and baseline frailty prevalence was 12.1 % (n = 288). Perceived age discrimination was reported by 38.4 % (n = 916) of the participants. Both frailty progression (OR 1.50, CI [1.26- 1.70]) and frailty development (OR 1.39, CI [1.14-1.62]) were significantly associated with perceived age discrimination in the fully adjusted models. Age (80+ years) (OR 3.72, CI [2.84-4.86]) and long-standing illness (OR 5.45, CI [4.43-6.67]) had the strongest association with respondents' frailty progression.
Perceived age discrimination significantly increased the risk of frailty progression and frailty development among ELSA participants.
随着衰弱给医疗保健资源带来的全球负担不断增加，了解衰弱的可改变风险因素非常重要。本研究探讨了感知年龄歧视是否是老年人衰弱进展和衰弱发生的潜在风险因素。
这是一项使用英国老龄化纵向研究（ELSA）第 5 波至第 9 波数据的前瞻性队列研究。仅在 ELSA 的第 5 波中收集了感知年龄歧视的数据，并将其作为本研究的基线数据进行分析。使用衰弱指数（FI）评分（范围为 0 至 1）定义衰弱，使用多维缺陷计算（评分≥0.25 被认为衰弱）。在 R 工作室中使用感知年龄歧视作为主要预测因子，使用年龄、性别、长期疾病、认知、主观社会地位（SSS）和心理健康作为协变量，拟合二项广义估计方程模型（GEE）。报告比值比及其 95%置信区间（CI）。
共有 2385 名 ELSA 参与者被纳入分析。55.8%（n=1312）为女性，平均年龄为 71.9（标准差±5.27）岁，基线衰弱患病率为 12.1%（n=288）。38.4%（n=916）的参与者报告了感知年龄歧视。在完全调整的模型中，衰弱进展（比值比 1.50，CI [1.26-1.70]）和衰弱发生（比值比 1.39，CI [1.14-1.62]）均与感知年龄歧视显著相关。年龄（80 岁以上）（比值比 3.72，CI [2.84-4.86]）和长期疾病（比值比 5.45，CI [4.43-6.67]）与受访者的衰弱进展相关性最强。
感知年龄歧视显著增加了 ELSA 参与者衰弱进展和衰弱发生的风险。
