Department of Medical Laboratory Science, Edo State University Uzairue, Benin, Nigeria.
Department of Medical Laboratory Science, Neuropsychiatric Hospital, Aro, Abeokuta, Nigeria.
Infect Disord Drug Targets. 2024;24(4):20-28. doi: 10.2174/0118715265251299231117045940.
Diphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not treated. The reemergence of diphtheria in Nigeria is most likely due to a combination of factors, including gaps in routine immunization regimens. The outbreak is further aggravated by multiple epidemics, which have diverted resources and attention away from the emergency of other infectious diseases. Furthermore, there is a lack of awareness of diphtheria in Nigeria. With a focus on the difficulties in controlling the disease, methods of diagnosis, available treatments, and preventive measures, this study provides a thorough analysis of diphtheria, covering its historical context, clinical presentation, associated complications, and current outbreaks. It emphasizes how important vaccination, early detection, and better access to healthcare are in reducing diphtheria outbreaks. The study highlights the serious effects of diphtheria on public health, particularly in regions with scarce resources and vaccine resistance, and offers a number of suggestions to overcome these challenges and prevent further outbreaks.
白喉是一种可通过疫苗预防的疾病,在尼日利亚卷土重来,近年来该国报告了多起疫情。疫情发生在全国各地,包括疫苗接种覆盖率较高的地区。白喉的病原体是一种高度传染性的细菌,可引起严重的呼吸道和全身症状,如果不治疗可能致命。白喉在尼日利亚再次出现,最可能是由于多种因素综合所致,包括常规免疫方案存在差距。此外,还有多重疫情,导致资源和注意力从其他传染病的紧急情况转移开来,进一步加剧了疫情。而且,尼日利亚对白喉的认识不足。本研究重点关注控制疾病的困难、诊断方法、可用的治疗方法和预防措施,对白喉进行了全面分析,涵盖了其历史背景、临床表现、相关并发症和当前疫情。它强调了疫苗接种、早期发现和更好地获得医疗保健在减少白喉疫情方面的重要性。该研究强调了白喉对公共卫生的严重影响,特别是在资源匮乏和疫苗耐药的地区,并提出了一些建议,以克服这些挑战并防止进一步爆发。