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天然产物治疗鼻咽癌的疗效。

The efficacy of natural products for the treatment of nasopharyngeal carcinoma.

机构信息

Department of Otolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Medical Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Chem Biol Drug Des. 2024 Jan;103(1):e14411. doi: 10.1111/cbdd.14411. Epub 2023 Dec 11.

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating in the nasopharyngeal epithelium with a high incidence in southern China and parts of Southeast Asia. The current treatment methods are mainly radiotherapy and chemotherapy. However, they often have side effects and are not suitable for long-term exposure. Natural products have received more and more attention in cancer prevention and treatment because of their its high efficiency, low toxic side effects, and low toxicity. Natural products can serve as a viable alternative, and this study aimed to review the efficacy and mechanisms of natural products in the treatment of NPC by examining previous literature. Most natural products act by inhibiting cell proliferation, metastasis, inducing cell cycle arrest, and apoptosis. Although further research is needed to verify their effectiveness and safety, natural products can significantly improve the treatment of NPC.

摘要

鼻咽癌(NPC)是一种起源于鼻咽部上皮的恶性肿瘤,在中国南方和东南亚部分地区发病率较高。目前的治疗方法主要是放疗和化疗。然而,它们往往有副作用,不适合长期暴露。由于天然产物具有高效、低毒副作用和低毒性等特点,在癌症预防和治疗方面受到越来越多的关注。天然产物可以作为一种可行的替代品,本研究旨在通过查阅以往文献,综述天然产物在治疗 NPC 中的疗效和作用机制。大多数天然产物通过抑制细胞增殖、转移、诱导细胞周期停滞和细胞凋亡来发挥作用。尽管还需要进一步研究来验证它们的有效性和安全性,但天然产物可以显著改善 NPC 的治疗效果。

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