Avizov Boris, Mirza Galib, Bargout Raed
Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Osteopathic Medicine, Midwestern University Arizona College of Osteopathic Medicine, Glendale, USA.
Cureus. 2023 Nov 7;15(11):e48475. doi: 10.7759/cureus.48475. eCollection 2023 Nov.
Various coronary artery anomalies have been identified in modern literature with most being benign in nature. Generally, these anomalous vessels are clinically silent due to their non-obstructive or benign course. It is vital to identify patients with malignant courses of these vessels as their initial presenting symptom might be sudden cardiac death. A 74-year-old male presented to the hospital following an episode of syncope and incontinence. Denying any symptoms of chest pain or shortness of breath, the patient did admit to having a six-month history of intermittent lightheadedness and one prior episode of syncope that was attributed to physical activity. Cardiac nuclear stress testing revealed a large reversible inferior wall defect indicating a defect with the right coronary artery. Cardiac catheterization demonstrated a history of coronary artery disease and revealed an anomalous origin of the right coronary artery. A coronary CT angiogram identified the right coronary artery as having an abnormal origin from the left sinus of Valsalva with a malignant interarterial route. The patient underwent a coronary artery bypass graft to correct the issue. There were no major postoperative complications. Treatment guidelines for patients suffering from malignant coronary artery anomalies are limited. Despite multiple surgical interventions available, data regarding conservative medical management is limited and should be of consideration in future studies.
现代文献中已发现多种冠状动脉异常情况,其中大多数本质上是良性的。一般来说,这些异常血管临床上没有症状,因为它们的行程无阻塞或呈良性。识别这些血管行程为恶性的患者至关重要,因为他们最初的症状可能是心源性猝死。一名74岁男性在发生一次晕厥和失禁后入院。患者否认有任何胸痛或呼吸急促症状,但承认有6个月间歇性头晕病史,且之前有过一次因体力活动导致的晕厥。心脏核素负荷试验显示下壁有一个大的可逆性缺损,提示右冠状动脉有缺损。心导管检查显示有冠状动脉疾病史,并发现右冠状动脉起源异常。冠状动脉CT血管造影确定右冠状动脉起源于左冠窦异常,走行呈恶性。患者接受了冠状动脉搭桥手术以纠正该问题。术后无重大并发症。针对患有恶性冠状动脉异常的患者的治疗指南有限。尽管有多种手术干预方法,但关于保守药物治疗的数据有限,应在未来研究中予以考虑。