Askarinejad Amir, Alizadehasl Azin, Jolfayi Amir Ghaffari, Adimi Sara
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR, Iran.
Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Cardiooncology. 2023 Dec 12;9(1):46. doi: 10.1186/s40959-023-00197-8.
Hypertension is one of the most common comorbidity and the leading cause of cancer-related death in cancer patients. The prevalence of hypertension in cancer patients is much higher than that of the general population. In the older population of cancer patients, specific cancer treatments such as new tyrosine kinase inhibitors and Vascular endothelial growth factor inhibitor drugs give rise to hypertension in cancer patients; The aim of present study is to provide a detailed discussion etiologies of cancer treatment-induced hypertension and explore the most innovative diagnostic and management approaches. This review will address the optimal approach to hypertension treatment, covering treatment initiation thresholds, targets, and the selection of anti-hypertensive agents. The lack of evidence in recent guidelines for managing cardiovascular toxicities in cancer patients can create uncertainty in clinicians' therapeutic and clinical decisions. This review aims to enhance our understanding of hypertension etiology in cancer patients and provide a practical guide to current treatment approaches.
高血压是癌症患者中最常见的合并症之一,也是癌症相关死亡的主要原因。癌症患者中高血压的患病率远高于普通人群。在老年癌症患者中,新的酪氨酸激酶抑制剂和血管内皮生长因子抑制剂等特定癌症治疗会导致癌症患者出现高血压;本研究的目的是详细讨论癌症治疗引起的高血压的病因,并探索最具创新性的诊断和管理方法。本综述将探讨高血压治疗的最佳方法,包括治疗起始阈值、目标以及抗高血压药物的选择。近期癌症患者心血管毒性管理指南中缺乏证据,可能会给临床医生的治疗和临床决策带来不确定性。本综述旨在加深我们对癌症患者高血压病因的理解,并为当前的治疗方法提供实用指南。