From the Pediatric Intensive Care Unit.
Department of Neurosurgery, General Children's Hospital "Panagiotis and Aglaia Kyriakou", Athens, Greece.
Pediatr Infect Dis J. 2024 Mar 1;43(3):e84-e86. doi: 10.1097/INF.0000000000004215. Epub 2023 Dec 13.
Acute necrotizing encephalopathy (ANE) is a rare childhood neurological disorder. The familiar type of ANE (ANE1) is associated with a mutation in the RANBP2 gene. Both SARS-CoV-2 and RANBP2 mutations are responsible for the manifestation of a hyper-inflammatory response that invades the central nervous system and plays a key role in the rapid progression of encephalopathy.
急性坏死性脑病（ANE）是一种罕见的儿童神经疾病。常见的 ANE 类型（ANE1）与 RANBP2 基因突变有关。SARS-CoV-2 和 RANBP2 突变均导致过度炎症反应的表现，该反应侵犯中枢神经系统，并在脑病的快速进展中起关键作用。
Zotero 插件