采用部分家庭治疗方案的光动力疗法治疗结节性基底细胞癌的初步研究长期随访结果

Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol.

作者信息

Salvio Ana Gabriela, Stringasci Mirian D, Requena Michelle B, Fregolenti Bianca A, Medeiro Maira Monique da Costa, Santos Rosilene Guedes, Bagnato Vanderlei Salvador

机构信息

Skin Department of Amaral Carvalho Hospital, Jaú, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil.

Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil.

出版信息

Photodiagnosis Photodyn Ther. 2024 Feb;45:103930. doi: 10.1016/j.pdpdt.2023.103930. Epub 2023 Dec 14.

DOI:10.1016/j.pdpdt.2023.103930

PMID:38103584

Abstract

SIGNIFICANCE

Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful.

APPROACH

Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm). Disease-free survival rate and pain score during irradiations were evaluated.

RESULTS

The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home.

CONCLUSIONS

A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results.

摘要

意义

评估一种用于低风险基底细胞癌（BCC）治疗的光动力疗法（PDT）方案，该方案所需的住院时间更短且疼痛更少。

方法

选取8例基底细胞癌，进行减瘤处理后，涂抹20%的氨基乙酰丙酸乳膏。3小时后，在医院进行首次照射（20分钟，150焦耳/平方厘米）。然后，重新涂抹乳膏，并将便携式照射原型固定在病灶周围的皮肤上。1.5小时后，患者在家中开启原型进行照射（2小时，总计312焦耳/平方厘米）。评估照射期间的无病生存率和疼痛评分。