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经导管主动脉瓣置换术后伴有预存右束支传导阻滞患者行永久起搏器植入的风险评估。

Risk Assessment of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation in Patients With Preexisting Right Bundle Branch Block.

机构信息

Department of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura City, Japan; Department of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.

Department of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura City, Japan.

出版信息

Am J Cardiol. 2024 Feb 15;213:151-160. doi: 10.1016/j.amjcard.2023.12.004. Epub 2023 Dec 15.

Abstract

Preexisting right bundle branch block (RBBB) is the strongest predictor for permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI). However, the risk assessment for new PPI and effective procedural strategy for preventing new PPI in patients with preexisting RBBB are still unclear. This study stratified the new PPI risk after TAVI and investigated the impact of implantation strategy in a preexisting RBBB cohort. We analyzed 237 patients with preexisting RBBB who underwent TAVI. The primary endpoint was the incidence of new PPI. Multivariate analyses investigating predictors for new PPI were performed. The overall PPI rate was 33.3%. Significant baseline predictors for new PPI were combination of RBBB, left anterior or posterior fascicular block, and first-degree atrioventricular block (odds ratio [OR] 2.55, 95% confidence interval [CI] 1.09 to 5.04), high calcium volume of noncoronary cusp (OR 2.08, 95% CI 1.05 to 4.10), and membranous septum (MS) length <2 mm (OR 2.02, 95% CI 1.09 to 3.75) in the univariate analysis and MS length <2 mm (OR 2.25, 95% CI 1.06 to 4.82) in the multivariate analysis. On the multivariate analysis including procedural variables, predilatation (OR 2.41, 95% CI 1.01 to 5.83), self-expanding valves (Corevalve, Evolut R, and Evolut Pro/Pro+; Medtronic Inc., Minneapolis, Minnesota) or mechanical expanding valves (Lotus/Lotus Edge; Boston Scientifics, Marlborough, Massachusetts) (OR 3.00, 95% CI 1.31 to 6.91), and implantation depth > MS length (OR 4.27, 95% CI 1.81 to 10.08) were significantly associated with new PPI. The incidence of new PPI increased according to the number of baseline predictors (0: 20.9%, 1: 34.3%, and ≥2: 52.0%) and procedural predictors (0: 3.7%, 1: 20.9%, 2: 40.5%, and 3: 60.0%). New PPI risk in a preexisting RBBB subset could be stratified by baseline factors. Device selection and implantation strategy considering MS length could prevent new PPI even in these high-risk population.

摘要

预先存在的右束支传导阻滞(RBBB)是经导管主动脉瓣植入(TAVI)后永久性起搏器植入(PPI)的最强预测因子。然而,对于预先存在 RBBB 患者的新 PPI 风险评估和预防新 PPI 的有效手术策略仍不清楚。本研究对 TAVI 后新 PPI 的风险进行了分层,并在预先存在 RBBB 的队列中研究了植入策略的影响。我们分析了 237 例预先存在 RBBB 的患者进行 TAVI。主要终点是新 PPI 的发生率。进行了多变量分析以调查新 PPI 的预测因素。整体 PPI 发生率为 33.3%。新 PPI 的显著基线预测因素是 RBBB 与左前或后束支阻滞以及一度房室传导阻滞的组合(比值比 [OR] 2.55,95%置信区间 [CI] 1.09 至 5.04)、非冠状动脉瓣叶的高钙体积(OR 2.08,95%CI 1.05 至 4.10)和中隔(MS)长度 <2mm(OR 2.02,95%CI 1.09 至 3.75)在单变量分析中,MS 长度 <2mm(OR 2.25,95%CI 1.06 至 4.82)在多变量分析中。在包括手术变量的多变量分析中,预扩张(OR 2.41,95%CI 1.01 至 5.83)、自扩张瓣膜(Corevalve、Evolut R 和 Evolut Pro/Pro+;美敦力公司,明尼苏达州明尼阿波利斯)或机械扩张瓣膜(Lotus/Lotus Edge;波士顿科学公司,马萨诸塞州马尔伯勒)(OR 3.00,95%CI 1.31 至 6.91)和植入深度>MS 长度(OR 4.27,95%CI 1.81 至 10.08)与新 PPI 显著相关。新 PPI 的发生率根据基线预测因素的数量(0:20.9%,1:34.3%,≥2:52.0%)和手术预测因素(0:3.7%,1:20.9%,2:40.5%,3:60.0%)而增加。预先存在 RBBB 亚组的新 PPI 风险可以通过基线因素进行分层。考虑到 MS 长度的设备选择和植入策略甚至可以预防这些高危人群的新 PPI。

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