局部或静脉给予氨甲环酸可加速伤口愈合。
Topical or intravenous administration of tranexamic acid accelerates wound healing.
机构信息
Düzce Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, 81000 Düzce, Türkiye.
出版信息
Jt Dis Relat Surg. 2024 Jan 1;35(1):85-95. doi: 10.52312/jdrs.2023.1044. Epub 2023 Nov 23.
OBJECTIVES
In this study, we aimed to investigate the morphological and histological effects of tranexamic acid (TA) on wound healing in a rat wound model.
MATERIALS AND METHODS
A total of 24 adult male Wistar Albino rats were used in this study. All rats were simple randomly divided into three groups including eight rats in each group. A full-thickness skin defect was created on the back of the rats in all groups. Serum physiological (2 mL) was instilled saline drops after wound formation (control group). Wound was created and topical TA (0.12 to 0.15 mL [30 mg/kg]) was applied (local group). Intravenous TA (0.12 to 0.15 mL [30 mg/kg]) was applied intravenously before the wound was created (intravenous group). The wound diameters of the groups were photographed and measured on Days 0, 3, 7, 10, 14 and, at the end of Day 14, the rats were sacrificed and their histopathological results and wound diameters were compared.
RESULTS
Fibroblast count values of the control group were found to be significantly lower than the local group (p=0.002), and no significant difference was observed between the local and intravenous groups (p>0.05). The collagen density (%) values of the control group were found to be significantly higher than the local and intravenous groups (p=0.016 and p=0.044). Wound diameter values of the control group on Day 10 day were found to be significantly higher than the local and intravenous groups (p=0.001). In addition, the wound diameter values of the control group on Day 14 were found to be significantly higher than the local and intravenous groups (p=0.001 and p=0.0001). The wound diameter changes of the control group on Days 0-10 were found to be significantly lower than the local and intravenous groups (p=0.001). In addition, the wound diameter changes of the control group on Days 0-14 were found to be lower than those of the local and intravenous groups (p=0.001 and p=0.0001).
CONCLUSION
The use of local or intravenous TA may have positive effects on the fibroblast count and wound contraction in a rat wound model.
目的
本研究旨在探讨氨甲环酸（TA）对大鼠创面模型愈合的形态和组织学影响。
材料和方法
本研究共使用 24 只成年雄性 Wistar 白化大鼠。所有大鼠均采用简单随机分组，每组 8 只。所有组均在背部造成全层皮肤缺损。形成创面后（对照组），局部滴注生理盐水（2 mL）。局部组（n=8）于创面形成后给予局部 TA（0.12 至 0.15 mL[30mg/kg]）。静脉组（n=8）于创面形成前静脉内给予 TA（0.12 至 0.15 mL[30mg/kg]）。于第 0、3、7、10、14 天拍摄并测量各组创面直径，并于第 14 天处死大鼠，比较其组织病理学结果和创面直径。
结果
对照组的成纤维细胞计数明显低于局部组（p=0.002），而局部组与静脉组之间无显著差异（p>0.05）。对照组的胶原密度（%）明显高于局部组和静脉组（p=0.016 和 p=0.044）。第 10 天，对照组的创面直径明显高于局部组和静脉组（p=0.001）。此外，第 14 天，对照组的创面直径明显高于局部组和静脉组（p=0.001 和 p=0.0001）。第 10 天，对照组的创面直径变化明显低于局部组和静脉组（p=0.001）。此外，第 14 天，对照组的创面直径变化明显低于局部组和静脉组（p=0.001 和 p=0.0001）。
结论
在大鼠创面模型中，局部或静脉内应用 TA 可能对成纤维细胞计数和创面收缩有积极影响。
Zotero 插件