性腺合成的甾体激素在结直肠癌微环境中的作用。
Role of gonadally synthesized steroid hormones in the colorectal cancer microenvironment.
作者信息
Wenxuan Liu, Liu Li, Zhang Lilong, Qiu Zhendong, Wu Zhongkai, Deng Wenhong
机构信息
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
出版信息
Front Oncol. 2023 Dec 5;13:1323826. doi: 10.3389/fonc.2023.1323826. eCollection 2023.
OBJECTIVE
To understand the relationship between steroid hormones synthesized by the gonads and colorectal cancer as well as its tumor microenvironment, in the expectation of providing new ideas in order to detect and treat colorectal cancer.
METHODS
Through reviewing the relevant literature at home and abroad, we summarized that androgens promote the growth of colorectal cancer, and estrogens and progesterone help prevent bowel cancer from developing; these three hormones also have a relevant role in the cellular and other non-cellular components of the tumor microenvironment of colorectal cancer.
CONCLUSION
The current literature suggests that androgens, estrogens, and progesterone are valuable in diagnosing and treating colorectal cancer, and that androgens promote the growth of colorectal cancer whereas estrogens and progesterone inhibit colorectal cancer, and that, in addition, the receptors associated with them are implicated in the modulation of a variety of cellular components of the microenvironment of colorectal cancer.
目的
了解性腺合成的甾体激素与结直肠癌及其肿瘤微环境之间的关系，以期为结直肠癌的检测和治疗提供新思路。
方法
通过查阅国内外相关文献，总结出雄激素促进结直肠癌生长，雌激素和孕激素有助于预防结直肠癌发展；这三种激素在结直肠癌肿瘤微环境的细胞及其他非细胞成分中也具有相关作用。
结论
目前的文献表明，雄激素、雌激素和孕激素在结直肠癌的诊断和治疗中具有重要价值，雄激素促进结直肠癌生长而雌激素和孕激素抑制结直肠癌，此外，与它们相关的受体参与调节结直肠癌微环境的多种细胞成分。
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