激肽对离体灌注大鼠肾脏的作用及肾脏B1受体存在的证据。
Effects of kinins on the isolated perfused rat kidney and evidence for the presence of renal B1 receptors.
作者信息
Guimarães J A, Vieira M A, Eich E, Maack T
出版信息
Adv Exp Med Biol. 1986;198 Pt A:559-62. doi: 10.1007/978-1-4684-5143-6_74.
PMID:3812094
Abstract
The kinins, particularly lysyl-bradykinin (LBK), have a bimodal effect on the vasculature of isolated rat kidney. The vasorelaxant but not the vasoconstrictor effect of LBK seems to be mediated by prostaglandins. The vasoconstrictor action of LBK can be blocked by (L-Leu)8-des-Arg9-BK indicating that the rat kidney vasculature has B1 kinin-receptor which mediates the effects of kinins and/or their C-terminal metabolites.
摘要
激肽，尤其是赖氨酰缓激肽（LBK），对离体大鼠肾脏血管具有双峰效应。LBK的血管舒张作用而非血管收缩作用似乎是由前列腺素介导的。LBK的血管收缩作用可被（L-亮氨酸）8-去-精氨酸9-缓激肽（BK）阻断，这表明大鼠肾脏血管具有B1激肽受体，该受体介导激肽及其C末端代谢产物的作用。
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