Feng Xinyuan, Deng Mingqun, Zhang Lina, Pan Qi
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing 100730 ,China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
J Transl Int Med. 2023 Dec 20;11(4):363-371. doi: 10.2478/jtim-2023-0116. eCollection 2023 Dec.
Diabetes and its complications are serious medical and global burdens, often manifesting as postprandial hyperglycemia. In recent years, considerable research attention has focused on relationships between the gut microbiota and circulating postprandial glucose (PPG). Different population studies have suggested that PPG is closely related to the gut microbiota which may impact PPG via short-chain fatty acids (SCFAs), bile acids (BAs) and trimethylamine N-oxide (TMAO). Studies now show that gut microbiota models can predict PPG, with individualized nutrition intervention strategies used to regulate gut microbiota and improve glucose metabolism to facilitate the precision treatment of diabetes. However, few studies have been conducted in patients with diabetes. Therefore, little is known about the relationships between the gut microbiota and PPG in this cohort. Thus, more research is required to identify key gut microbiota and associated metabolites and pathways impacting PPG to provide potential therapeutic targets for PPG.
糖尿病及其并发症是严重的医学和全球负担，常表现为餐后高血糖。近年来，大量研究关注集中在肠道微生物群与循环餐后血糖（PPG）之间的关系上。不同的人群研究表明，PPG与肠道微生物群密切相关，肠道微生物群可能通过短链脂肪酸（SCFAs）、胆汁酸（BAs）和氧化三甲胺（TMAO）影响PPG。目前的研究表明，肠道微生物群模型可以预测PPG，可采用个性化营养干预策略来调节肠道微生物群并改善葡萄糖代谢，以促进糖尿病的精准治疗。然而，针对糖尿病患者的研究较少。因此，对于该队列中肠道微生物群与PPG之间的关系知之甚少。因此，需要更多的研究来确定影响PPG的关键肠道微生物群、相关代谢物和途径，为PPG提供潜在的治疗靶点。
