Mushtaq Naureen, Ul Ain Rahat, Hamid Syed Ahmer, Bouffet Eric
Division of Pediatric Oncology, Department of Oncology, Aga Khan University, Karachi 74800, Pakistan.
Department of Pediatric Hematology/Oncology & Bone Marrow Transplant, University of Child Health Sciences, Children's Hospital, Lahore 54600, Pakistan.
Diagnostics (Basel). 2023 Dec 16;13(24):3680. doi: 10.3390/diagnostics13243680.
The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review.
在过去的四十年里,儿童髓母细胞瘤的治疗发生了巨大变化,旨在提高生存率和降低高剂量颅脊髓放疗长期毒性的化疗方案不断发展。虽然直到最近髓母细胞瘤的分期和治疗仍基于改良的Chang系统,但髓母细胞瘤分子生物学的最新进展彻底改变了这种日益复杂疾病的管理方法。本综述描述了全身治疗的演变。