Plano Federica, Shekarkar Azgomi Mojtaba, Corsale Anna Maria, Spoto Corinne, Caccamo Nadia, Meraviglia Serena, Dieli Francesco, D'Angelo Paolo, Trizzino Antonino, Siragusa Sergio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.
Department of Biomedicine, Neurosciences and Advanced Diagnosis, University of Palermo, 90127 Palermo, Italy.
Hematol Rep. 2023 Dec 8;15(4):707-716. doi: 10.3390/hematolrep15040071.
This study delves into the intricate landscape of SARS-CoV-2 vaccine response in immunodeficient patients, focusing on the dynamics of both humoral and cell-mediated immunity. The cohort includes patients with common variable immunodeficiency (CVI), agammaglobulinemia (XLA), and combined immunodeficiency (CI). The findings reveal varying degrees of antibody production, with XLA patients exhibiting no measurable response but displaying a robust T-cell-mediated response. The study emphasizes the importance of considering both arms of the immune system in assessing vaccine immunogenicity, particularly in the context of immunodeficiency. The results challenge conventional measures of vaccine efficacy only based on antibody titers, highlighting the need for a more comprehensive understanding of the immune response in this vulnerable population. This research contributes valuable insights to guide clinical decisions regarding vaccination strategies, booster doses, and overall protection in immunodeficient individuals.
本研究深入探讨了免疫缺陷患者中SARS-CoV-2疫苗反应的复杂情况，重点关注体液免疫和细胞介导免疫的动态变化。该队列包括常见可变免疫缺陷（CVI）、无丙种球蛋白血症（XLA）和联合免疫缺陷（CI）患者。研究结果显示出不同程度的抗体产生，XLA患者未表现出可测量的反应，但显示出强大的T细胞介导反应。该研究强调在评估疫苗免疫原性时考虑免疫系统两个分支的重要性，特别是在免疫缺陷的情况下。结果挑战了仅基于抗体滴度的传统疫苗效力衡量标准，突出了对这一脆弱人群免疫反应进行更全面理解的必要性。这项研究为指导免疫缺陷个体的疫苗接种策略、加强剂量和整体保护方面的临床决策提供了有价值的见解。
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