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2型糖尿病中NAFLD的非侵入性诊断及风险分层:优势与局限

Non-Invasive Diagnostic of NAFLD in Type 2 Diabetes Mellitus and Risk Stratification: Strengths and Limitations.

作者信息

Boeriu Alina, Dobru Daniela, Fofiu Crina

机构信息

Gastroenterology Department, University of Medicine Pharmacy, Sciences, and Technology "George Emil Palade" Targu Mures, 540142 Targu Mures, Romania.

Gastroenterology Department, Mures County Clinical Hospital, 540103 Targu Mures, Romania.

出版信息

Life (Basel). 2023 Nov 27;13(12):2262. doi: 10.3390/life13122262.

Abstract

The progressive potential of liver damage in type 2 diabetes mellitus (T2DM) towards advanced fibrosis, end-stage liver disease, and hepatocarcinoma has led to increased concern for quantifying liver injury and individual risk assessment. The combination of blood-based markers and imaging techniques is recommended for the initial evaluation in NAFLD and for regular monitoring to evaluate disease progression. Continued development of ultrasonographic and magnetic resonance imaging methods for accurate quantification of liver steatosis and fibrosis, as well as promising tools for the detection of high-risk NASH, have been noted. In this review, we aim to summarize available evidence regarding the usefulness of non-invasive methods for the assessment of NAFLD in T2DM. We focus on the power and limitations of various methods for diagnosis, risk stratification, and patient monitoring that support their implementation in clinical setting or in research field.

摘要

2型糖尿病(T2DM)导致的肝损伤向晚期纤维化、终末期肝病和肝癌发展的潜在可能性,已引发了人们对量化肝损伤和个体风险评估的更多关注。对于非酒精性脂肪性肝病(NAFLD)的初始评估以及定期监测以评估疾病进展,建议采用血液标志物和成像技术相结合的方法。超声和磁共振成像方法在准确量化肝脏脂肪变性和纤维化方面不断发展,同时也出现了一些用于检测高危非酒精性脂肪性肝炎(NASH)的有前景的工具。在本综述中,我们旨在总结关于非侵入性方法评估T2DM中NAFLD有用性的现有证据。我们重点关注各种诊断、风险分层和患者监测方法的优势与局限性,这些方法支持它们在临床环境或研究领域中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aca/10744403/0a80b0c602ef/life-13-02262-g001.jpg

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