Dimitriadis Konstantinos, Katelani Stamatia, Pappa Maria, Fragkoulis George E, Androutsakos Theodoros
Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
First Department of Internal Medicine, Propaedeutic Clinic, "Laiko" Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
J Pers Med. 2023 Nov 30;13(12):1675. doi: 10.3390/jpm13121675.
Hepatitis B virus (HBV) infection is a worldwide medical issue with significant morbidity and mortality, as it is the main cause of chronic liver disease and hepatocellular carcinoma (HCC). Both innate and adaptive immune responses play a key role in HBV replication and suppression. Recently, the pathophysiological function of interleukins (IL) in the natural course of HBV has gained much attention as a result of the broad use of anti-interleukin agents for a variety of autoimmune diseases and the accompanying risk of HBV reactivation. We present a narrative review regarding the role of IL in HBV infection. Collectively, the pro-inflammatory ILs, namely IL-1, IL-5, IL-6, IL-12 and IL-21, seem to play a critical role in the suppression of HBV replication. In contrast, the anti-inflammatory cytokines IL-10, IL-23 and IL-35 probably act as HBV replication enhancers, while IL-17 has been correlated with HBV-related liver injury. Interestingly enough, IL-2, IL-4 and IL-12 have been tried as therapeutic options against HBV infection with contradictory results. Lastly, the role of IL-22 remains largely ill defined, although preliminary data suggest that it may play a significant role in HBV replication, proliferation and subsequent liver damage.
乙型肝炎病毒（HBV）感染是一个全球性的医学问题，具有很高的发病率和死亡率，因为它是慢性肝病和肝细胞癌（HCC）的主要病因。先天性和适应性免疫反应在HBV复制和抑制中都起着关键作用。近年来，由于抗白细胞介素药物在多种自身免疫性疾病中的广泛应用以及随之而来的HBV再激活风险，白细胞介素（IL）在HBV自然病程中的病理生理功能备受关注。我们对IL在HBV感染中的作用进行了叙述性综述。总体而言，促炎细胞因子IL-1、IL-5、IL-6、IL-12和IL-21似乎在抑制HBV复制中起关键作用。相反，抗炎细胞因子IL-10、IL-23和IL-35可能作为HBV复制增强剂，而IL-17与HBV相关肝损伤有关。有趣的是，IL-2、IL-4和IL-12已被尝试作为抗HBV感染的治疗选择，但结果相互矛盾。最后，IL-22的作用在很大程度上仍不明确，尽管初步数据表明它可能在HBV复制、增殖及随后的肝损伤中起重要作用。
