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建立模型以研究医院病床和疫苗接种对传染病动态的影响。

Modeling the impact of hospital beds and vaccination on the dynamics of an infectious disease.

机构信息

Department of Mathematics, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.

Department of Mathematics, University of Sussex, Falmer, Brighton, BN1 9QH, United Kingdom.

出版信息

Math Biosci. 2024 Feb;368:109133. doi: 10.1016/j.mbs.2023.109133. Epub 2023 Dec 23.

Abstract

The unprecedented scale and rapidity of dissemination of re-emerging and emerging infectious diseases impose new challenges for regulators and health authorities. To curb the dispersal of such diseases, proper management of healthcare facilities and vaccines are core drivers. In the present work, we assess the unified impact of healthcare facilities and vaccination on the control of an infectious disease by formulating a mathematical model. To formulate the model for any region, we consider four classes of human population; namely, susceptible, infected, hospitalized, and vaccinated. It is assumed that the increment in number of beds in hospitals is continuously made in proportion to the number of infected individuals. To ensure the occurrence of transcritical, saddle-node and Hopf bifurcations, the conditions are derived. The normal form is obtained to show the existence of Bogdanov-Takens bifurcation. To validate the analytically obtained results, we have conducted some numerical simulations. These results will be useful to public health authorities for planning appropriate health care resources and vaccination programs to diminish prevalence of infectious diseases.

摘要

重新出现和新出现的传染病的空前规模和传播速度给监管机构和卫生当局带来了新的挑战。为了遏制此类疾病的传播,对医疗保健设施和疫苗进行适当的管理是核心驱动因素。在本工作中,我们通过制定一个数学模型来评估医疗保健设施和疫苗接种对传染病控制的统一影响。为了为任何地区制定模型,我们考虑了四类人群;即易感人群、感染人群、住院人群和接种人群。假设医院床位数量的增加与感染人数成比例持续增加。为了确保发生跨临界、鞍结和 Hopf 分岔,我们推导出了条件。得到正规形以显示 Bogdanov-Takens 分岔的存在。为了验证分析得到的结果,我们进行了一些数值模拟。这些结果将有助于公共卫生当局规划适当的医疗保健资源和疫苗接种计划,以减少传染病的流行。

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