Department of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Department of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Front Immunol. 2023 Dec 11;14:1242302. doi: 10.3389/fimmu.2023.1242302. eCollection 2023.
Sleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.
In this prospective observational study, we investigated the influence of sleep habits on immune acquisition induced by mRNA vaccines against SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range, 33.0-44.0 years) from June 2021 to January 2022. The study measured sleep duration using actigraphy and sleep diaries, which covered the periods of the initial and booster vaccinations.
Multivariable linear regression analysis showed that actigraphy-measured objective sleep duration 3 and 7 days after the booster vaccination was independently and significantly correlated with higher antibody titers (B=0.003; 95% confidence interval, 0.000-0.005; Beta=0.337; p=0.02), even after controlling for covariates, including age, sex, the type of vaccine, and reactogenicity to the vaccination. Associations between acquired antibody titer and average objective sleep duration before vaccination, and any period of subjective sleep duration measured by sleep diary were negligible.
Longer objective, but not subjective, sleep duration after booster vaccination enhances antibody response. Hence, encouraging citizens to sleep longer after mRNA vaccination, especially after a booster dose, may increase protection against SARS-CoV-2.
This study is registered at the University Hospital Medical Information Network Center (UMIN: https://www.umin.ac.jp) on July 30, 2021, #UMIN000045009.
睡眠可增强对疫苗的抗体反应，但睡眠与针对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的 mRNA 疫苗接种之间的关系尚未完全阐明。
在这项前瞻性观察研究中，我们调查了 48 名健康成年人（BNT-162b2，n=34；mRNA-1273，n=14；女性，n=30，62.5%；男性，n=18，37.5%；中位年龄，39.5 岁；四分位间距，33.0-44.0 岁）接种 SARS-CoV-2 mRNA 疫苗后，睡眠习惯对免疫获得的影响。这些成年人在 2021 年 6 月至 2022 年 1 月期间接种了初始和加强针疫苗。该研究使用活动记录仪和睡眠日记来测量睡眠持续时间，这些日记涵盖了初始和加强接种期间。
多变量线性回归分析表明，加强针接种后 3 天和 7 天的活动记录仪测量的客观睡眠时间与更高的抗体滴度独立且显著相关（B=0.003；95%置信区间，0.000-0.005；β=0.337；p=0.02），即使在控制了年龄、性别、疫苗类型和接种反应性等混杂因素后也是如此。接种前平均客观睡眠时间和任何主观睡眠时间与获得的抗体滴度之间的关联可忽略不计。
加强针接种后较长的客观睡眠时间而非主观睡眠时间可增强抗体反应。因此，鼓励公民在 mRNA 接种后，尤其是加强针接种后，增加睡眠时间，可能会增加对 SARS-CoV-2 的保护。
本研究于 2021 年 7 月 30 日在大学医院医疗信息网络中心（UMIN：https://www.umin.ac.jp）注册，#UMIN000045009。
Zotero 插件