日本版临床痴呆评定量表加国立阿尔茨海默病协调中心行为和语言域在日本散发性额颞叶痴呆中的效用。
Utility of the Japanese version of the Clinical Dementia Rating® plus National Alzheimer's Coordinating Centre Behaviour and Language Domains for sporadic cases of frontotemporal dementia in Japan.
机构信息
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Psychiatry, Esaka Hospital, Suita, Japan.
出版信息
Psychogeriatrics. 2024 Mar;24(2):281-294. doi: 10.1111/psyg.13072. Epub 2023 Dec 28.
BACKGROUND
We aimed to validate the Clinical Dementia Rating (CDR®) dementia staging instrument plus the National Alzheimer's Coordinating Centre Behaviour and Language Domains (CDR® plus NACC FTLD) for use in clinical settings in Japan and in the Japanese language.
METHODS
This prospective observational study enrolled 29 patients with frontotemporal dementia (FTD) and 21 patients with Alzheimer's disease (AD) dementia from the Departments of Psychiatry at Osaka University Hospital and Asakayama General Hospital and the Brain Function Centre at Nippon Life Hospital. CDR® plus NACC FTLD, CDR®, Mini-Mental State Examination (MMSE), Western Aphasia Battery (WAB), Neuropsychiatric Inventory-plus (NPI-plus), Stereotypy Rating Inventory (SRI), and frontal behavioural symptom scores obtained from items of NPI-plus and SRI, were conducted to assess inter- and intra-rater reliability, validity, and responsiveness. We performed receiver operating characteristic (ROC) curve analysis to evaluate the discriminating power of the Behaviour/Comportment/Personality (BEHAV) and Language (LANG) domains of the CDR® plus NACC FTLD and the MEMORY domain of the CDR® in patients AD dementia and FTD.
RESULTS
The CDR® plus NACC FTLD showed good inter- and intra-rater reliabilities. In patients with FTD, the BEHAV domain of the CDR® plus NACC FTLD was significantly correlated with all clinical measures except for the SRI total score, while the LANG domain of the CDR® plus NACC FTLD was significantly correlated with the MMSE and the WAB-Aphasia quotient. In addition, the CDR® plus NACC FTLD sum of boxes significantly changed after 6 months and after 1 year. ROC curve analysis showed that the BEHAV and LANG domains of the CDR® plus NACC FTLD distinguished between patients with AD dementia and FTD better than the MEMORY domain of the CDR®.
CONCLUSIONS
This study validated the Japanese version of the CDR® plus NACC FTLD with good reliability, validity, and responsiveness.
背景
我们旨在验证临床痴呆评定量表（CDR®）加国家阿尔茨海默病协调中心行为和语言领域（CDR®加 NACC FTLD），以便在日本的临床环境中使用，并以日语呈现。
方法
这项前瞻性观察研究纳入了来自大阪大学医院、朝上山综合医院精神科以及日本生命医院脑功能中心的 29 例额颞叶痴呆（FTD）患者和 21 例阿尔茨海默病（AD）痴呆患者。采用 CDR®加 NACC FTLD、CDR®、简易精神状态检查（MMSE）、西部失语症成套测验（WAB）、神经精神问卷加（NPI-plus）、刻板行为评定量表（SRI）和 NPI-plus 与 SRI 项目中的额叶行为症状评分，评估其内部和外部信度、效度和反应性。我们进行了受试者工作特征（ROC）曲线分析，以评估 CDR®加 NACC FTLD 的行为/行为/人格（BEHAV）和语言（LANG）领域以及 CDR®的 MEMORY 领域在 AD 痴呆和 FTD 患者中的区分能力。
结果
CDR®加 NACC FTLD 具有良好的内部和外部信度。在 FTD 患者中，CDR®加 NACC FTLD 的 BEHAV 领域与除 SRI 总分外的所有临床指标均显著相关，而 CDR®加 NACC FTLD 的 LANG 领域与 MMSE 和 WAB 失语商显著相关。此外，CDR®加 NACC FTLD 的总框数在 6 个月和 1 年后显著改变。ROC 曲线分析表明，CDR®加 NACC FTLD 的 BEHAV 和 LANG 领域比 CDR®的 MEMORY 领域能更好地区分 AD 痴呆和 FTD 患者。
结论
本研究验证了具有良好信度、效度和反应性的 CDR®加 NACC FTLD 的日语版本。
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