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单中心研究:局部麻醉与全身麻醉用于慢性硬脑膜下血肿清除术的效果比较。

Single-Center Comparison of Chronic Subdural Hematoma Evacuation Outcomes Under Local Versus General Anesthesia.

机构信息

Medical Faculty, Uzhhorod National University, Uzhhorod, Ukraine; Municipal Non-Profit Enterprise "Regional Clinic, Center of Neurosurgery and Neurology" Transcarpathian Regional Council, Uzhhorod, Ukraine.

Medical Faculty, Uzhhorod National University, Uzhhorod, Ukraine.

出版信息

World Neurosurg. 2024 Apr;184:e39-e44. doi: 10.1016/j.wneu.2023.12.116. Epub 2023 Dec 26.

Abstract

BACKGROUND

Chronic subdural hematoma (CSDH) is a neurosurgical pathology of an aged populace. Pathogenetic risk factors include traumatic brain injury, prolonged use of antiplatelet drugs, hypertension, and some inflammatory processes. The incidence increases as patients age. Burr-hole evacuation is the most common approach in management of symptomatic cases. We compared evacuation of chronic subdural hematomas with general or local anesthesia (GA and LA, respectively) and evaluated the safety, economic benefits, effects of comorbidity, benefits, and shortcomings of both techniques.

METHODS

We conducted a retrospective study of 67 consecutive patients who had 74 procedures for CSDH in a single neurosurgical center, the Regional Clinic, Centre of Neurosurgery and Neurology, over a 3-year period. They were grouped into the GA group (n = 44) and LA group (n = 23). Mean duration of procedure, length of hospital stay, complications, and preoperative and postoperative neurologic statuses were compared. The distribution of nominal variables between groups was compared using the Fisher exact test. The average duration of operation and length of hospital stay were compared using the Mann-Whitney U-test due to violation of the normality assumption.

RESULTS

LA proved to be as effective as GA in CSDH evacuation. Seventy-four surgical procedures were performed on 67 patients due to recurrence in less than 30 days in 7 patients. Fifteen patients had tension pneumocephalus managed with fluid therapy to full recovery. LA was economical and required shorter hospital stays and surgical time.

CONCLUSIONS

In our studies, LA proved to be noninferior to GA, time conserving, and less prone to some of the adverse effects of GA on elderly patients with comorbidity, although some patients who are hyperactive or contraindicated to LA will require GA.

摘要

背景

慢性硬脑膜下血肿(CSDH)是老年人的神经外科病理学。发病的危险因素包括创伤性脑损伤、抗血小板药物的长期使用、高血压和一些炎症过程。随着患者年龄的增长,发病率增加。骨孔清除术是治疗有症状病例的最常见方法。我们比较了全身麻醉(GA)和局部麻醉(LA)在慢性硬脑膜下血肿清除术中的效果,并评估了两种技术的安全性、经济效益、合并症的影响、优势和不足。

方法

我们对在一个神经外科中心(Regional Clinic,Centre of Neurosurgery and Neurology)进行的 67 例连续患者的 74 例 CSDH 手术进行了回顾性研究,该研究在 3 年内进行。他们被分为 GA 组(n=44)和 LA 组(n=23)。比较了手术持续时间、住院时间、并发症以及术前和术后神经状态。使用 Fisher 确切检验比较组间名义变量的分布。由于违反正态性假设,使用 Mann-Whitney U 检验比较手术平均持续时间和住院时间。

结果

LA 在 CSDH 清除中与 GA 一样有效。由于 7 例患者在 30 天内复发,对 67 例患者进行了 74 次手术。15 例张力性气颅患者通过液体治疗完全康复。LA 经济实惠,住院时间和手术时间更短。

结论

在我们的研究中,LA 被证明在非劣效性、节省时间和对合并症的老年患者的 GA 的一些不良反应的易感性方面优于 GA,尽管一些多动或对 LA 禁忌的患者将需要 GA。

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