印度医学生的血源感染和乙型肝炎病毒免疫水平。
Blood borne infections and Hepatitis B virus immunization levels among medical students in India.
机构信息
State Level -Viral Research and Diagnostic Laboratory (VRDL), Department of Microbiology, Maulana Azad Medical College & Associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
出版信息
Indian J Med Microbiol. 2024 Jan-Feb;47:100525. doi: 10.1016/j.ijmmb.2023.100525. Epub 2024 Jan 3.
BACKGROUND
Medical students are actively involved in direct patient care during their training and subsequent medical practice, making them susceptible to acquiring blood-borne pathogens, including HBV. This study aimed to assess the occurrence of blood-borne infections and the Hepatitis B immunization status among medical students. Furthermore, it sought to identify gaps in risk assessment for blood-borne pathogens among medical students at a Medical College in New Delhi.
METHODS
The study included 108 medical students who participated in a blood donation camp. Blood samples collected from these individuals underwent testing for blood-borne pathogens in accordance with standard screening protocols at the blood bank. The quantitative estimation was performed for anti-HBs IgG using ELISA.
RESULTS
All 108 participants were pursuing their undergraduate or postgraduate medical degrees. All students tested negative for HBsAg and HIV markers and showed no reactivity to Syphilis and Malaria. However, one student tested positive for HCV. Two postgraduate students had a history of needlestick injuries. Eighty-one (75%) students had received Hepatitis B vaccination. Among the vaccinated students, 34 (41.97%) were immunized before the age of five years, 22 (27.16%) after the age of five years, while 25 (30.86%) couldn't recall the exact age of their Hepatitis B vaccination. Protective anti-HBs titer of anti-Hepatitis B antibodies (>10 mIU/ml) were detected in 48.15% (52/108) of students.
CONCLUSIONS
Over 50% of medical students did not possess sufficient immunity against HBV infection, putting them at a heightened risk of acquiring HBV during their active participation in patient care in the near future. It is imperative to establish a policy for routine anti-HBs titer assessment and ensure easy access to Hepatitis B immunization for medical students, thereby enhancing their protection against this infectious agent.
背景
医学生在培训和后续的医疗实践中直接接触患者,因此易感染血源性病原体,包括乙型肝炎病毒(HBV)。本研究旨在评估医学生血源性感染的发生情况和乙型肝炎疫苗免疫状况,并确定新德里一所医学院医学生血源性病原体风险评估中的差距。
方法
本研究纳入了 108 名参加献血活动的医学生。采集这些个体的血液样本,按照血库的标准筛查方案进行血源性病原体检测。采用 ELISA 法对乙型肝炎表面抗体(抗-HBs IgG)进行定量估计。
结果
所有 108 名参与者均攻读本科或研究生医学学位。所有学生的乙型肝炎表面抗原(HBsAg)和人类免疫缺陷病毒(HIV)标志物检测均为阴性,对梅毒和疟疾均无反应。然而,有 1 名学生丙型肝炎病毒(HCV)检测呈阳性。有 2 名研究生有针刺伤史。81 名(75%)学生接受了乙型肝炎疫苗接种。在已接种疫苗的学生中,34 名(41.97%)在 5 岁之前接种,22 名(27.16%)在 5 岁之后接种,而 25 名(30.86%)记不清自己接种乙型肝炎疫苗的确切年龄。在 108 名学生中,48.15%(52/108)检测到乙型肝炎表面抗体(抗-HBs)的保护性抗体滴度(>10 mIU/ml)。
结论
超过 50%的医学生对乙型肝炎病毒感染没有足够的免疫力,这使他们在未来积极参与患者护理时面临感染乙型肝炎病毒的高风险。必须制定常规抗-HBs 滴度评估政策,并确保医学生容易获得乙型肝炎免疫接种,从而增强他们对这种感染因子的保护。