1例L-天冬酰胺酶诱导的严重肝脂肪变性伴血清胆碱酯酶水平降低
A Case of L-Asparaginase-Induced Severe Hepatic Steatosis With Decreased Serum Cholinesterase Levels.
作者信息
Takata Kazuhide, Nakashima Yuta, Shakado Satoshi, Takamatsu Yasushi, Hirai Fumihito
机构信息
Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Fukuoka, JPN.
Department of Internal Medicine, Fukuoka University Faculty of Medicine, Fukuoka, JPN.
出版信息
Cureus. 2023 Dec 1;15(12):e49787. doi: 10.7759/cureus.49787. eCollection 2023 Dec.
L-asparaginase (L-Asp) is a useful antileukemic agent for acute lymphoblastic leukemia (ALL); however, it often causes severe liver injury with marked fatty liver. Here, we present a case of L-Asp-induced fatty liver disease in a 21-year-old female patient with ALL. Serum cholinesterase levels, which are usually elevated in fatty liver, decrease at the onset of liver injury. After treatment with L-carnitine and vitamin B complex, the liver injury rapidly improved, resulting in the patient being able to continue subsequent chemotherapy.
L-天冬酰胺酶（L-Asp）是一种用于治疗急性淋巴细胞白血病（ALL）的有效抗白血病药物；然而，它常导致严重的肝损伤并伴有明显的脂肪肝。在此，我们报告一例21岁ALL女性患者发生L-Asp诱导的脂肪性肝病的病例。血清胆碱酯酶水平在脂肪肝时通常会升高，但在肝损伤发作时会降低。经L-肉碱和复合维生素B治疗后，肝损伤迅速改善，使患者能够继续后续化疗。
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