Clinical Systems Biology Research Laboratories, Translational Medicine Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.
J Zhejiang Univ Sci B. 2024 Jan 15;25(1):1-22. doi: 10.1631/jzus.B2300097.
Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.
心血管疾病 (CVDs) 是全球死亡率的主要驱动因素。铁是一种必需的痕量矿物质,在许多生物过程中都很重要,其在 CVDs 中的作用引起了数十年来的广泛讨论。铁介导的细胞死亡,即铁死亡,由于其在心肌细胞损伤和 CVDs 中的关键作用而引起了广泛关注。此外,铁蛋白自噬是诱导铁死亡的上游机制,与 CVDs 密切相关。本综述旨在描述铁死亡和铁蛋白自噬的过程和机制,以及铁蛋白自噬涉及的调节途径和分子靶点,并确定它们在 CVDs 中的作用。此外,我们还讨论了靶向铁蛋白自噬诱导的铁死亡调节剂治疗 CVDs 的可能性。总之,本综述为 CVDs 的病理学提供了一些新的见解,并确定了可能的治疗靶点。