Department of Food Engineering and Technology, Faculty of Food Engineering, University of Campinas, 13083-862 Campinas, Brazil.
Department of Food Engineering and Technology, Faculty of Food Engineering, University of Campinas, 13083-862 Campinas, Brazil; CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal; LABBELS - Associate Laboratory, Braga/Guimarães, Portugal.
Food Res Int. 2024 Jan;176:113821. doi: 10.1016/j.foodres.2023.113821. Epub 2023 Dec 4.
The use of lipids from conventional oils and fats to produce solid lipid nanoparticles (SLN) attracting interest from the food industry, since due their varying compositions directly affects crystallization behavior, stability, and particle sizes (PS) of SLN. Thus, this study aimed evaluate the potential of fully hydrogenated oils (hardfats) with different hydrocarbon chain lengths to produce SLN using different emulsifiers. For that, fully hydrogenated palm kern (FHPkO), palm (FHPO), soybean (FHSO), microalgae (FHMO) and crambe (FHCO) oils were used. Span 60 (S60), soybean lecithin (SL), and whey protein isolate (WPI) were used as emulsifiers. The physicochemical characteristics and crystallization properties of SLN were evaluated during 60 days. Results indicates that the crystallization properties were more influenced by the hardfat used. SLN formulated with FHPkO was more unstable than the others, and hardfats FHPO, FHSO, FHMO, and FHCO exhibited the appropriate characteristics for use to produce SLN. Concerning emulsifiers, S60- based SLN showed high instability, despite the hardfat used. SL-based and WPI-based SLN formulations, showed a great stability, with crystallinity properties suitable for food incorporation.
传统油脂中的脂质用于生产固体脂质纳米粒（SLN），这引起了食品工业的兴趣，因为其组成的变化直接影响 SLN 的结晶行为、稳定性和颗粒大小（PS）。因此，本研究旨在评估具有不同碳氢链长度的全氢化油（硬脂）在使用不同乳化剂的情况下生产 SLN 的潜力。为此，使用了全氢化棕榈仁油（FHPkO）、棕榈油（FHPO）、大豆油（FHSO）、微藻油（FHMO）和荠籽油（FHCO）。Span 60（S60）、大豆卵磷脂（SL）和乳清蛋白分离物（WPI）用作乳化剂。在 60 天内评估了 SLN 的理化特性和结晶性能。结果表明，结晶性能更多地受到硬脂的影响。用 FHPkO 制备的 SLN 比其他 SLN 更不稳定，而 FHPO、FHSO、FHMO 和 FHCO 硬脂具有适合用于生产 SLN 的特性。关于乳化剂，基于 S60 的 SLN 尽管使用了硬脂，但显示出高度的不稳定性。基于 SL 和 WPI 的 SLN 制剂表现出很好的稳定性，结晶性能适合食品添加。
Pak J Biol Sci. 2012-2-1
Eur J Pharm Biopharm. 2007-8
Drug Deliv Transl Res. 2025-5-7
Recent Pat Nanotechnol. 2025
Zotero 插件