Li Zhiwen, Zhang Jingjing, Li Gao, Puddephatt Richard J
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Nat Commun. 2024 Jan 2;15(1):154. doi: 10.1038/s41467-023-44302-y.
Molecular knots, whose synthesis presents many challenges, can play important roles in protein structure and function as well as in useful molecular materials, whose properties depend on the size of the knotted structure. Here we report the synthesis by self-assembly of molecular trefoil metallaknot with formula [Au{1,2-CH(OCHCC)}{PhP(CH)PPh}], Au, from three units of each of the components 1,2-CH(OCHCCAu) and PhP(CH)PPh. Structure determination by X-ray diffraction revealed that the chiral trefoil knot contains only 54 atoms in the backbone, so that Au is the smallest and tightest molecular trefoil knot known to date.
分子结的合成面临诸多挑战，它在蛋白质结构与功能以及有用的分子材料中都能发挥重要作用，这些材料的性质取决于打结结构的大小。在此，我们报告了分子式为[Au{1,2-CH(OCHCC)}{PhP(CH)PPh}]Au的分子三叶金属结通过自组装的合成方法，该分子结由1,2-CH(OCHCCAu)和PhP(CH)PPh这两种组分各三个单元组成。通过X射线衍射确定结构表明，这种手性三叶结的主链仅包含54个原子，因此Au是迄今为止已知的最小且最紧密的分子三叶结。
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