Dop Dalia, Marcu Iulia Rahela, Padureanu Vlad, Caragea Daniel Cosmin, Padureanu Rodica, Niculescu Stefan-Adrian, Niculescu Carmen Elena
Department of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Biomed Rep. 2023 Dec 8;20(2):18. doi: 10.3892/br.2023.1706. eCollection 2024 Feb.
infection (CDI) is the most common cause of healthcare-associated diarrhea and among adults, the worldwide incidence rate of the infection is increasing. There is a small amount of data in the literature for pediatric patients, but most indicate an increasing trend. is a constituent of the normal microbiota; however, under specific conditions that cause a disruption of the normal bacterial flora, colonization of and the released toxins that cause inflammation and mucosal damage occurs. Risk factors for CDI at any age include hospitalization, exposure to antibiotics, administration of proton pump inhibitors, invasive mechanical ventilation, immunosuppression and presence of associated comorbidities. Clinical manifestations range from asymptomatic colonization to fulminant disease characterized by toxic megacolon, intestinal perforation and, rarely, death. The aim of the present review was to outline the features of CDI in pediatric patients.
艰难梭菌感染（CDI）是医疗保健相关腹泻的最常见原因，在成年人中，该感染的全球发病率正在上升。文献中关于儿科患者的数据较少，但大多数表明呈上升趋势。艰难梭菌是正常微生物群的组成部分；然而，在导致正常细菌菌群破坏的特定条件下，艰难梭菌会定植并释放毒素，从而引起炎症和粘膜损伤。任何年龄段CDI的危险因素包括住院、接触抗生素、使用质子泵抑制剂、有创机械通气、免疫抑制以及存在相关合并症。临床表现从无症状定植到以中毒性巨结肠、肠穿孔以及罕见的死亡为特征的暴发性疾病不等。本综述的目的是概述儿科患者CDI的特征。
