Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Department of Gastrointestinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Curr Top Med Chem. 2024;24(3):179-191. doi: 10.2174/0115680266279228231219101233.
Signaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific proteases (USPs) account for the majority of protein deubiquitination activities. In addition to transcriptional and post-translational regulation, ubiquitination plays an important role in the regulation of key proteins. There is a possibility that altered biological processes may lead to serious human diseases, including cancer. Recent studies have revealed the role of USPs in hepatocellular carcinoma tumorigenesis. The purpose of this review is to summarize the involvement of this class of enzymes in the regulation of cell signaling in hepatocellular carcinoma and the therapeutic development of inhibitors that target USPs, which may lead to novel therapies to treat hepatocellular carcinoma.
肝细胞癌中的信号通路主要通过翻译后蛋白质的磷酸化和泛素化来介导。在哺乳动物细胞中，泛素特异性蛋白酶（USP）占大多数蛋白质去泛素化活性。除了转录和翻译后调控，泛素化在关键蛋白的调控中也发挥着重要作用。改变的生物学过程可能导致严重的人类疾病，包括癌症。最近的研究揭示了 USPs 在肝细胞癌肿瘤发生中的作用。本文综述的目的是总结这一类酶在调节肝细胞癌细胞信号中的作用，以及针对 USPs 的抑制剂的治疗开发，这可能为治疗肝细胞癌提供新的治疗方法。
