Cheng Huai, Zhang Hewei, Cai Huanchang, Liu Min, Wen Shubo, Ren Jingqiang
Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, China.
College of Food and Drugs, Luoyang Polytechnic, Luoyang, China.
Front Microbiol. 2023 Dec 20;14:1282112. doi: 10.3389/fmicb.2023.1282112. eCollection 2023.
Canine parainfluenza virus (CPIV) is a zoonotic virus that is widely distributed and is the main pathogen causing canine infectious respiratory disease (CIRD), also known as "kennel cough," in dogs. The CPIV-V protein is the only nonstructural protein of the virus and plays an important role in multiple stages of the virus life cycle by inhibiting apoptosis, altering the host cell cycle and interfering with the interferon response. In addition, studies have shown that the V protein has potential applications in the field of immunotherapy in oncolytic virus therapy or self-amplifying RNA vaccines. In this review, the biosynthesis, structural characteristics and functions of the CPIV-V protein are reviewed with an emphasis on how it facilitates viral immune escape and its potential applications in the field of immunotherapy. Therefore, this review provides a scientific basis for research into the CPIV-V protein and its potential applications.
犬副流感病毒（CPIV）是一种人畜共患病毒，广泛分布，是引起犬传染性呼吸道疾病（CIRD，也称为“犬窝咳”）的主要病原体。CPIV-V蛋白是该病毒唯一的非结构蛋白，通过抑制细胞凋亡、改变宿主细胞周期和干扰干扰素反应，在病毒生命周期的多个阶段发挥重要作用。此外，研究表明，V蛋白在溶瘤病毒疗法或自我扩增RNA疫苗的免疫治疗领域具有潜在应用。在本综述中，对CPIV-V蛋白的生物合成、结构特征和功能进行了综述，重点关注其如何促进病毒免疫逃逸及其在免疫治疗领域的潜在应用。因此，本综述为CPIV-V蛋白及其潜在应用的研究提供了科学依据。
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