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胆囊癌伴弥漫性骨转移。

Gallbladder carcinoma presenting with disseminated bony metastasis.

机构信息

Medical Oncology, Tata Main Hospital, Jamshedpur, Jharkhand, India

Medical Oncology, Meherbai Tata Memorial Hospital, Jamshedpur, Jharkhand, India.

出版信息

BMJ Case Rep. 2024 Jan 4;17(1):e257753. doi: 10.1136/bcr-2023-257753.

Abstract

Gallbladder cancer (GBC) is the 23rd most common cancer worldwide and one of the three leading cancers in North and Northeast India. GBC has inferior outcomes due to its advanced presentation and poor response to chemotherapy. The approximate 5-year survival rate for metastatic GBC is less than 5%, with a median survival of around 6 months. Distant metastases from GBC to the bones happen in the later part of the natural history of the disease. Presentation with bony metastasis is infrequent, and less than 25 cases have been reported. Our case was an elderly man in his 70s who presented with back pain and, on workup, was detected to have adenocarcinoma of the gall bladder with disseminated lytic bony metastasis without any visceral metastasis. This case describes the natural history of such cases and discusses the role of bone scan or fluorodeoxyglucose positron emission tomography in the workup for GBC.

摘要

胆囊癌 (GBC) 是全球第 23 种最常见的癌症,也是印度北部和东北部三种主要癌症之一。由于其晚期表现和对化疗的反应不佳,GBC 的治疗效果较差。转移性 GBC 的 5 年生存率约为 5%,中位生存期约为 6 个月。GBC 向骨骼的远处转移发生在疾病自然史的后期。骨转移的表现并不常见,报道的病例少于 25 例。我们的病例是一名 70 多岁的老年男性,因背痛就诊,在检查中发现患有胆囊腺癌,并伴有弥漫性溶骨性骨转移,无任何内脏转移。本病例描述了此类病例的自然病史,并讨论了骨扫描或氟脱氧葡萄糖正电子发射断层扫描在 GBC 检查中的作用。

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