可见光光氧化还原催化吲哚与一氧化碳及α-氨基烷基自由基前体的分子间α-氨甲基/羧基化脱芳构化反应
Visible-Light Photoredox-Catalyzed Intermolecular α-Aminomethyl/Carboxylative Dearomatization of Indoles with CO and α-Aminoalkyl Radical Precursors.
作者信息
Gao Wanxu, Yang Qi, Yang Han, Yao Yang, Bai Junxue, Sun Jianwei, Sun Song
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Department of Chemistry, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
出版信息
Org Lett. 2024 Jan 19;26(2):467-472. doi: 10.1021/acs.orglett.3c03755. Epub 2024 Jan 5.
Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential α-aminomethyl/carboxylative dearomatization of indoles with CO and α-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity. This multicomponent reaction provides a green and facile method for the synthesis of diverse functionalized indolines by using CO as the carboxylic and carbonyl source.
本文公开了一种可见光光氧化还原催化的吲哚与一氧化碳和α-氨基烷基自由基前体的分子间顺序α-氨甲基/羧基化脱芳构化反应，以良好的产率和高区域选择性得到一系列官能化的吲哚啉-3-羧酸和内酰胺。该多组分反应通过使用一氧化碳作为羧基和羰基源，为合成各种官能化吲哚啉提供了一种绿色且简便的方法。
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