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[帕金森病和震颤综合征中的附加功能症状]

[Additional functional symptoms in Parkinson's disease and tremor syndromes].

作者信息

Zeuner Kirsten E, Schwingenschuh Petra

机构信息

Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Christian-Albrechts-Universität Kiel, Arnold-Heller-Str. 3 Haus 41, 24105, Kiel, Deutschland.

Universitätsklinik für Neurologie, Medizinische Universität Graz, Graz, Österreich.

出版信息

Nervenarzt. 2024 Jun;95(6):525-531. doi: 10.1007/s00115-023-01594-1. Epub 2024 Jan 5.

Abstract

Patients with Parkinson's Disease or a tremor syndrome may present with additional functional movement disorders. The differential diagnosis is particularly difficult. In some cases, functional symptoms occur either before the manifestation of the organic disease or can emerge as an additional symptom after Parkinson's disease or tremor became apparent. In patients with Parkinson's disease the prevalence for additional functional symptoms is 7 %. In the case that patients with Parkinson's diseases have one side that is more severely affected, additional functional motor symptoms such as functional rest tremor also occur on that same, predominantly affected side. Functional gait disorders occur frequently. Clinically, patients appear notably slow in automatized, daily tasks. Their speech is more whispering than hypophonic, bradykinesia during finger tapping manifest without a decrement. The Dopamintransporterszintigraphy (123) I FP-CIT SPECT; DaTSCANTM) may be helpful to differentiate between functional Parkinsonism and Parkinson's disease. Functional tremor in patients with an organic tremor syndrome is diagnosed with the same distraction techniques as in solely functional tremor. This includes cognitive, motor, and suggestive distraction maneuvers. In some cases, additional neurophysiological investigations such as accelerometry are useful for the differential diagnosis. It is most important to identify patients with additional functional symptoms in non-functional movement disorders, because the therapeutic approach differs and a multi professional team is required to initiate effective treatment strategies.

摘要

帕金森病或震颤综合征患者可能会出现其他功能性运动障碍。鉴别诊断尤为困难。在某些情况下,功能性症状要么在器质性疾病表现之前出现,要么在帕金森病或震颤明显后作为附加症状出现。帕金森病患者出现附加功能性症状的患病率为7%。在帕金森病患者中,如果一侧受影响更严重,同一主要受影响侧也会出现诸如功能性静止性震颤等附加功能性运动症状。功能性步态障碍很常见。临床上,患者在日常自动化任务中明显动作迟缓。他们的言语更多是低语而非音量减弱,手指敲击时的运动迟缓表现无递减。多巴胺转运体闪烁扫描(123I FP-CIT SPECT;DaTSCAN™)可能有助于区分功能性帕金森综合征和帕金森病。器质性震颤综合征患者的功能性震颤与单纯功能性震颤的诊断采用相同的分散注意力技术。这包括认知、运动和暗示性分散注意力动作。在某些情况下,诸如加速度测量等额外的神经生理学检查对鉴别诊断有用。识别非功能性运动障碍中伴有附加功能性症状的患者非常重要,因为治疗方法不同,需要多专业团队来启动有效的治疗策略。

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