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大脑中动脉近端未破裂梭形动脉瘤的血流导向治疗

Flow diversion for unruptured fusiform aneurysms of the proximal middle cerebral artery.

作者信息

Gai Yanting, Nuerdong Maimaitiali, Jiang Yicheng, Wang Wei, Pu Benfang, Xu Feng, Song Donglei

机构信息

Department of Neurosurgery, Shanghai Donglei Brain Hospital, Shanghai, China.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

出版信息

Front Neurol. 2023 Dec 14;14:1325983. doi: 10.3389/fneur.2023.1325983. eCollection 2023.

Abstract

BACKGROUND

Managing fusiform aneurysms of the proximal (M1) segment of the middle cerebral artery (MCA) is challenging due to difficulties in both surgical and endovascular treatment. In this study, we present our experience using flow diverter stents for managing unruptured M1 segment fusiform aneurysms.

METHODS

We conducted a retrospective review of the database of our institution to identify all patients who underwent flow diversion treatment for unruptured M1 segment fusiform aneurysms. We collected data on patient demographics, aneurysm characteristics, complications, angiographic follow-up results, and clinical outcomes.

RESULTS

A total of 10 patients (five male and five female patients) with 10 unruptured M1 segment fusiform aneurysms were included in the study. The average age of the patients was 48 years (range: 16-64 years); five patients had aneurysms smaller than 10 mm, four had aneurysms measuring between 10 and 25 mm, and one patient had an aneurysm larger than 25 mm. The successful deployment of flow-diverting stents was achieved in all cases. Procedure-related morbidity was observed in 10% of patients, but there were no deaths. All patients showed good outcomes (modified Rankin Scale score of 0-1); eight out of 10 patients had available follow-up angiography results with a mean follow-up period of 11.6 months (range: 6-24 months). Complete occlusion occurred in six out of eight reviewed cases (75%).

CONCLUSION

Our preliminary findings suggest that using flow diversion for treating unruptured fusiform aneurysms in the proximal MCA is feasible and safe, with a satisfactory rate of complete occlusion. However, further studies involving larger case series are needed to validate the durability and efficacy of this treatment approach.

摘要

背景

由于手术和血管内治疗都存在困难,大脑中动脉(MCA)近端(M1)段梭形动脉瘤的管理具有挑战性。在本研究中,我们介绍了使用血流导向支架治疗未破裂M1段梭形动脉瘤的经验。

方法

我们对本机构的数据库进行了回顾性研究,以确定所有接受血流导向治疗未破裂M1段梭形动脉瘤的患者。我们收集了患者的人口统计学数据、动脉瘤特征、并发症、血管造影随访结果和临床结局。

结果

本研究共纳入10例未破裂M1段梭形动脉瘤患者(5例男性和5例女性)。患者的平均年龄为48岁(范围:16 - 64岁);5例患者的动脉瘤小于10 mm,4例患者的动脉瘤大小在10至25 mm之间,1例患者的动脉瘤大于25 mm。所有病例均成功植入血流导向支架。10%的患者出现与手术相关的并发症,但无死亡病例。所有患者预后良好(改良Rankin量表评分为0 - 1);10例患者中有8例有可用的随访血管造影结果,平均随访期为11.6个月(范围:6 - 24个月)。8例复查病例中有6例(75%)实现完全闭塞。

结论

我们的初步研究结果表明,采用血流导向治疗MCA近端未破裂梭形动脉瘤是可行且安全的,完全闭塞率令人满意。然而,需要进一步开展涉及更大病例系列的研究来验证这种治疗方法的持久性和有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e47/10773848/486094aead94/fneur-14-1325983-g0001.jpg

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