免疫组织化学检测在膀胱尿路上皮癌中雄激素受体的表达。这有意义吗？来自印度沿海地区的经验。
Immunohistochemical expression of androgen receptors in urothelial carcinoma of urinary bladder. Is it significant? Experience from coastal India.
机构信息
Kasturba Medical College, Mangalore, Manipal Academy of Higher education, Manipal, Karnataka.
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka.
出版信息
Arch Ital Urol Androl. 2023 Nov 15;95(4):11514. doi: 10.4081/aiua.2023.11514.
BACKGROUND
Bladder carcinoma (BC) ranks second among the genitourinary cancers worldwide. Influence of androgens and expression of androgen receptors in neoplasms are recent findings which were implicated in the development of BC. We aimed to study androgen receptor (AR) expression in bladder urothelial neoplasms and correlate its expression with grade and stage of the tumor.
METHODS
Immunohistochemistry (IHC) was done on samples collected in a tertiary care hospital over one year consisting of 71 urothelial BC and 20 non-neoplastic urothelial conditions. Two pathologists graded the IHC and nuclear staining was considered as positive expression.
RESULTS
AR was expressed in 23.9% (17/71) of bladder urothelial neoplasms. AR was expressed in 25.7% and 22.3% of high and low-grade tumors and 25% and 22.3% of non muscle-invasive and muscle-invasive BC. AR expression had no significant correlation with gender, age (> 50 years), muscle invasion or grade. AR expression was significantly absent in non-neoplastic conditions (p = 0.018).
CONCLUSIONS
AR has varied expression in BC and it is relatively lower in this study population.
背景
膀胱癌（BC）在全球泌尿生殖系统癌症中排名第二。雄激素的影响和雄激素受体在肿瘤中的表达是最近的发现，这些发现与 BC 的发展有关。我们旨在研究膀胱癌中雄激素受体（AR）的表达，并将其表达与肿瘤的分级和分期相关联。
方法
在一家三级保健医院收集了一年的样本，其中包括 71 例膀胱尿路上皮癌和 20 例非肿瘤性尿路上皮病变。两名病理学家对免疫组织化学（IHC）进行了分级，核染色被认为是阳性表达。
结果
AR 在 23.9%（17/71）的膀胱尿路上皮肿瘤中表达。AR 在高分级和低分级肿瘤中的表达率分别为 25.7%和 22.3%，在非肌层浸润性和肌层浸润性 BC 中的表达率分别为 25%和 22.3%。AR 表达与性别、年龄（>50 岁）、肌肉浸润或分级均无显著相关性。AR 在非肿瘤性病变中表达显著缺失（p=0.018）。
结论
AR 在 BC 中有不同的表达，在本研究人群中相对较低。
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