Li Amber Xinyu, Martin Tracey A, Lane Jane, Jiang Wen G
Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Cancers (Basel). 2023 Dec 22;16(1):76. doi: 10.3390/cancers16010076.
Striatins (STRNs) are generally considered to be cytoplasmic proteins, with lower expression observed in the nucleus and at cell-cell contact regions. Together with protein phosphatase 2A (PP2A), STRNs form the core region of striatin-interacting phosphatase and kinase (STRIPAK) complexes through the coiled-coil region of STRN proteins, which is crucial for substrate recruitment. Over the past two decades, there has been an increasing amount of research into the biological and cellular functions of STRIPAK members. STRNs and the constituent members of the STRIPAK complex have been found to regulate several cellular functions, such as cell cycle control, cell growth, and motility. Dysregulation of these cellular events is associated with cancer development. Importantly, their roles in cancer cells and clinical cancers are becoming recognised, with several STRIPAK components found to have elevated expression in cancerous tissues compared to healthy tissues. These molecules exhibit significant diagnostic and prognostic value across different cancer types and in metastatic progression. The present review comprehensively summarises and discusses the current knowledge of STRNs and core STRIPAK members, in cancer malignancy, from both cellular and clinical perspectives.
条纹蛋白（STRNs）通常被认为是细胞质蛋白，在细胞核和细胞间接触区域的表达较低。STRNs与蛋白磷酸酶2A（PP2A）一起，通过STRN蛋白的卷曲螺旋区域形成条纹蛋白相互作用磷酸酶和激酶（STRIPAK）复合物的核心区域，这对于底物募集至关重要。在过去的二十年中，对STRIPAK成员的生物学和细胞功能的研究越来越多。已发现STRNs和STRIPAK复合物的组成成员可调节多种细胞功能，如细胞周期控制、细胞生长和运动。这些细胞事件的失调与癌症发展有关。重要的是，它们在癌细胞和临床癌症中的作用正逐渐得到认可，与健康组织相比，几种STRIPAK成分在癌组织中的表达升高。这些分子在不同癌症类型和转移进展中具有显著的诊断和预后价值。本综述从细胞和临床角度全面总结并讨论了STRNs和核心STRIPAK成员在癌症恶性肿瘤方面的现有知识。
