Dhaliwal Galvin, Patrone Michael V, Bickston Stephen J
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, VA 23219, USA.
J Clin Med. 2023 Dec 31;13(1):251. doi: 10.3390/jcm13010251.
Patients diagnosed with inflammatory bowel disease (IBD), which encompasses Crohn's disease and ulcerative colitis, experience chronic inflammation of the gastrointestinal tract. Those with IBD face a higher risk of developing venous thromboembolism (VTE) compared to individuals without IBD. This escalated risk is associated with various factors, some modifiable and others non-modifiable, with disease activity being the primary concern. Interestingly, Janus Kinase inhibitors approved for the treatment of IBD may be associated with an increased risk of VTE but only in patients that have other underlying risk factors leading to an overall increased VTE risk. Several recognized medical societies have recommended the use of VTE prophylaxis for hospitalized individuals with IBD. The association between VTE and IBD and the need for pharmacologic prophylaxis remains under-recognized. Increased awareness of this complication can hopefully protect patients from a potentially deadly complication.
被诊断患有炎症性肠病(IBD)(包括克罗恩病和溃疡性结肠炎)的患者会经历胃肠道的慢性炎症。与没有IBD的个体相比,IBD患者发生静脉血栓栓塞(VTE)的风险更高。这种风险的增加与多种因素相关,有些因素是可改变的,有些则不可改变,其中疾病活动是主要关注点。有趣的是,被批准用于治疗IBD的Janus激酶抑制剂可能与VTE风险增加有关,但仅在有其他导致VTE总体风险增加的潜在危险因素的患者中如此。几个知名医学协会已建议对住院的IBD患者使用VTE预防措施。VTE与IBD之间的关联以及药物预防的必要性仍未得到充分认识。提高对这种并发症的认识有望保护患者免受潜在的致命并发症的影响。